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- W2740904530 abstract "Radioimmunoscintigraphy (RIS) is a technique which uses radiolabeled antibodies to visualize tumors, taking advantage of antigens preferentially expressed by malignant tissues. Human epithelial mucin, MUC1, is commonly over expressed in adenocarcinomas including 80% of breast cancers and represents a useful target for RIS. The PR81 is a new murine anti-MUC1 monoclonal antibody that was found to react with the membrane extracts of several human breast cancer tissues and the cell surface of MUC1 positive cell lines. In this study we have developed a direct method for labeling of this MAb with Tc which is simple, rapid, efficient and particularly suitable for development of a ‘kit’. The quality control of new radiopharmaceutical and immunoscintigraphy studies in BALB/c mice bearing breast tumor xenografts were also performed." @default.
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- W2740904530 date "2008-01-01" @default.
- W2740904530 modified "2023-09-23" @default.
- W2740904530 title "99m Tc direct labeling of a new anti-MUC1 monoclonal antibody, PR81, as a potential agent for imaging of human breast cancer in nuclear medicine" @default.
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