Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740907975> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2740907975 abstract "The role of cell free DNA (cfDNA) has been intensively dis cussed under various pathological conditions and after acute bouts of exercise. To date, there is still no conclusive evidence concerning the cellular origin of cfDNA and the entire mecha nism leading to elevated cfDNA concentrations in human plasma and serum. Here, we investigated the cellular origin of cfDNA in sex-mismatched haematopoietic stem cell trans plantation (HSCT) and liver transplantation (LT) patients by determining the relative proportion of Y-chromosomal to total nuclear cfDNA. Total nuclear cfDNA and Y-chromosomal cfDNA concentrations were determined in blood plasma before and after an incremental exercise test via quantitative real-time PCR (qPCR). Female HSCT patients showed high proportions of Y-chromosomal cfDNA. Both total nuclear and Y-chromosomal cfDNA increased significantly and in a highly correlated fashion due to exercise. In male HSCT patients with female donors less than 10% of the cfDNA was of Y-chro mosomal origin at any point in time and even though the total amount of cfDNA increased during exercise, no increases in Y-chromosomal DNA could be detected. The percentage of Ychromosomal cfDNA in female LT patients with male donors was very low and levels remained unchanged during exercise. This indicates that cells not derived from the bone marrow, in this case transplanted liver cells, represented only a minor fraction of cfDNA in blood plasma and were not released dur ing acute physical exercise. Even though many physiological conditions may be altered in transplant patients versus healthy people, our results strongly suggest that cells from the haematopoietic lineage are the main source of cfDNA released during acute bouts of exercise." @default.
- W2740907975 created "2017-08-08" @default.
- W2740907975 creator A5007997327 @default.
- W2740907975 creator A5030598868 @default.
- W2740907975 creator A5048410356 @default.
- W2740907975 creator A5072195182 @default.
- W2740907975 date "2015-01-01" @default.
- W2740907975 modified "2023-09-24" @default.
- W2740907975 title "exercise-induced increases in cel l free Dna in human pl asma originat e predominant l y from cel l s of t he haemat opoiet ic l ineage" @default.
- W2740907975 cites W1249058925 @default.
- W2740907975 cites W1496811300 @default.
- W2740907975 cites W1507812324 @default.
- W2740907975 cites W1637508783 @default.
- W2740907975 cites W1645433395 @default.
- W2740907975 cites W1963853602 @default.
- W2740907975 cites W1968899195 @default.
- W2740907975 cites W1981105071 @default.
- W2740907975 cites W1987211914 @default.
- W2740907975 cites W1992319055 @default.
- W2740907975 cites W199361062 @default.
- W2740907975 cites W1994474089 @default.
- W2740907975 cites W1995897388 @default.
- W2740907975 cites W2003475924 @default.
- W2740907975 cites W2016599680 @default.
- W2740907975 cites W2017324325 @default.
- W2740907975 cites W2024692616 @default.
- W2740907975 cites W2033900516 @default.
- W2740907975 cites W2040898123 @default.
- W2740907975 cites W2064622831 @default.
- W2740907975 cites W2084690793 @default.
- W2740907975 cites W2086052543 @default.
- W2740907975 cites W2088512088 @default.
- W2740907975 cites W2092741900 @default.
- W2740907975 cites W2096643260 @default.
- W2740907975 cites W2107303448 @default.
- W2740907975 cites W2109130949 @default.
- W2740907975 cites W2113473782 @default.
- W2740907975 cites W2115829250 @default.
- W2740907975 cites W2123582374 @default.
- W2740907975 cites W2131641641 @default.
- W2740907975 cites W2135672265 @default.
- W2740907975 cites W2146597362 @default.
- W2740907975 cites W2148803850 @default.
- W2740907975 cites W2164320986 @default.
- W2740907975 cites W2166362034 @default.
- W2740907975 cites W2171170913 @default.
- W2740907975 cites W2325725613 @default.
- W2740907975 hasPublicationYear "2015" @default.
- W2740907975 type Work @default.
- W2740907975 sameAs 2740907975 @default.
- W2740907975 citedByCount "0" @default.
- W2740907975 crossrefType "journal-article" @default.
- W2740907975 hasAuthorship W2740907975A5007997327 @default.
- W2740907975 hasAuthorship W2740907975A5030598868 @default.
- W2740907975 hasAuthorship W2740907975A5048410356 @default.
- W2740907975 hasAuthorship W2740907975A5072195182 @default.
- W2740907975 hasConcept C109159458 @default.
- W2740907975 hasConcept C126322002 @default.
- W2740907975 hasConcept C134018914 @default.
- W2740907975 hasConcept C152110520 @default.
- W2740907975 hasConcept C16685009 @default.
- W2740907975 hasConcept C172680121 @default.
- W2740907975 hasConcept C2778258057 @default.
- W2740907975 hasConcept C2779234561 @default.
- W2740907975 hasConcept C28328180 @default.
- W2740907975 hasConcept C42407357 @default.
- W2740907975 hasConcept C54355233 @default.
- W2740907975 hasConcept C71924100 @default.
- W2740907975 hasConcept C86803240 @default.
- W2740907975 hasConceptScore W2740907975C109159458 @default.
- W2740907975 hasConceptScore W2740907975C126322002 @default.
- W2740907975 hasConceptScore W2740907975C134018914 @default.
- W2740907975 hasConceptScore W2740907975C152110520 @default.
- W2740907975 hasConceptScore W2740907975C16685009 @default.
- W2740907975 hasConceptScore W2740907975C172680121 @default.
- W2740907975 hasConceptScore W2740907975C2778258057 @default.
- W2740907975 hasConceptScore W2740907975C2779234561 @default.
- W2740907975 hasConceptScore W2740907975C28328180 @default.
- W2740907975 hasConceptScore W2740907975C42407357 @default.
- W2740907975 hasConceptScore W2740907975C54355233 @default.
- W2740907975 hasConceptScore W2740907975C71924100 @default.
- W2740907975 hasConceptScore W2740907975C86803240 @default.
- W2740907975 hasLocation W27409079751 @default.
- W2740907975 hasOpenAccess W2740907975 @default.
- W2740907975 hasPrimaryLocation W27409079751 @default.
- W2740907975 hasRelatedWork W2600928146 @default.
- W2740907975 hasRelatedWork W3086450882 @default.
- W2740907975 isParatext "false" @default.
- W2740907975 isRetracted "false" @default.
- W2740907975 magId "2740907975" @default.
- W2740907975 workType "article" @default.