Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740911569> ?p ?o ?g. }
- W2740911569 endingPage "462" @default.
- W2740911569 startingPage "452" @default.
- W2740911569 abstract "Purpose of review The current article reviews the rationale, sources and preparation of pig islets for xenotransplantation, and presents current progress in solving the problems associated with establishing pig islet transplant as a clinical treatment for type 1 diabetes. Summary Islet transplantation is an effective treatment option for type 1 diabetes, but the available supply of human pancreases is insufficient to meet the need and demand for obtaining islets. Pig islets provide a readily available source for islet transplantation, with trials in non-human primates demonstrating their potential to reverse diabetes. The risk of zoonosis can be reduced by designated pathogen-free breeding of the donor pigs, but porcine endogenous retroviruses (PERVs) that are integrated into the genome of all pigs are especially difficult to eliminate. However, clinical trials have demonstrated an absence of PERV transmission with a significant reduction in the number of severe hypoglycemic episodes and up to 30% reduction in exogenous insulin doses. A number of methods such as production of various transgenic pigs to better xenotransplantation efficiency and the encapsulation of islets to isolate them from the host immune system are currently being tested to overcome the xenograft immune rejection. Furthermore, ongoing research is also shedding light on factors such as the age and breed of the donor pig to determine the optimal islet quantity and function." @default.
- W2740911569 created "2017-08-08" @default.
- W2740911569 creator A5007431205 @default.
- W2740911569 creator A5009856948 @default.
- W2740911569 creator A5020209065 @default.
- W2740911569 creator A5031500611 @default.
- W2740911569 creator A5072419465 @default.
- W2740911569 creator A5089664464 @default.
- W2740911569 creator A5090507736 @default.
- W2740911569 date "2017-10-01" @default.
- W2740911569 modified "2023-09-25" @default.
- W2740911569 title "Pig islet xenotransplantation" @default.
- W2740911569 cites W1082065364 @default.
- W2740911569 cites W1462368826 @default.
- W2740911569 cites W1526477243 @default.
- W2740911569 cites W1527713817 @default.
- W2740911569 cites W1532468082 @default.
- W2740911569 cites W1546331692 @default.
- W2740911569 cites W1579420638 @default.
- W2740911569 cites W1583259015 @default.
- W2740911569 cites W1614547515 @default.
- W2740911569 cites W1669156028 @default.
- W2740911569 cites W1712381933 @default.
- W2740911569 cites W1779021762 @default.
- W2740911569 cites W1835735948 @default.
- W2740911569 cites W1886595183 @default.
- W2740911569 cites W1928404074 @default.
- W2740911569 cites W1964125065 @default.
- W2740911569 cites W1964130048 @default.
- W2740911569 cites W1965158070 @default.
- W2740911569 cites W1966377914 @default.
- W2740911569 cites W1966549112 @default.
- W2740911569 cites W1966606022 @default.
- W2740911569 cites W1967464350 @default.
- W2740911569 cites W1970376329 @default.
- W2740911569 cites W1972229141 @default.
- W2740911569 cites W1975251263 @default.
- W2740911569 cites W1976350274 @default.
- W2740911569 cites W1976370313 @default.
- W2740911569 cites W1979411388 @default.
- W2740911569 cites W1980671129 @default.
- W2740911569 cites W1981640498 @default.
- W2740911569 cites W1985734511 @default.
- W2740911569 cites W1986514663 @default.
- W2740911569 cites W1990408758 @default.
- W2740911569 cites W1991220499 @default.
- W2740911569 cites W1996642604 @default.
- W2740911569 cites W1998411289 @default.
- W2740911569 cites W1998944797 @default.
- W2740911569 cites W2000051120 @default.
- W2740911569 cites W2000548361 @default.
- W2740911569 cites W2000955386 @default.
- W2740911569 cites W2001278124 @default.
- W2740911569 cites W2001327882 @default.
- W2740911569 cites W2003296334 @default.
- W2740911569 cites W2004126648 @default.
- W2740911569 cites W2004300459 @default.
- W2740911569 cites W2005505795 @default.
- W2740911569 cites W2006085167 @default.
- W2740911569 cites W2013050720 @default.
- W2740911569 cites W2014774429 @default.
- W2740911569 cites W2016124159 @default.
- W2740911569 cites W2017653928 @default.
- W2740911569 cites W2020458810 @default.
- W2740911569 cites W2021414568 @default.
- W2740911569 cites W2021509402 @default.
- W2740911569 cites W2024711583 @default.
- W2740911569 cites W2033085754 @default.
- W2740911569 cites W2034627511 @default.
- W2740911569 cites W2036996065 @default.
- W2740911569 cites W2038173080 @default.
- W2740911569 cites W2038921447 @default.
- W2740911569 cites W2039343099 @default.
- W2740911569 cites W2040049973 @default.
- W2740911569 cites W2041002133 @default.
- W2740911569 cites W2044959759 @default.
- W2740911569 cites W2048399630 @default.
- W2740911569 cites W2049786642 @default.
- W2740911569 cites W2050735645 @default.
- W2740911569 cites W2052166643 @default.
- W2740911569 cites W2053081561 @default.
- W2740911569 cites W2054577535 @default.
- W2740911569 cites W2055227797 @default.
- W2740911569 cites W2056623826 @default.
- W2740911569 cites W2057691895 @default.
- W2740911569 cites W2061009859 @default.
- W2740911569 cites W2063369149 @default.
- W2740911569 cites W2063929679 @default.
- W2740911569 cites W2067092189 @default.
- W2740911569 cites W2074332806 @default.
- W2740911569 cites W2074699984 @default.
- W2740911569 cites W2075307702 @default.
- W2740911569 cites W2076372531 @default.
- W2740911569 cites W2077105492 @default.
- W2740911569 cites W2078835422 @default.
- W2740911569 cites W2079799920 @default.
- W2740911569 cites W2080031707 @default.
- W2740911569 cites W2081592312 @default.