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- W2740961745 abstract "Clostridium difficile infection (CDI) is a major public health problem worldwide. Treatment has become complicated due to the emergence of strains with increased toxigenicity and sporulation rate, together with rampant antibiotics use that disrupts colonization resistance of the colonic microbiota. As a result, there is a critical need for nonantibiotic treatments. Therapies based on inhibiting the toxins, bacterial structures responsible for colonization, virulence and restoration of the gut microbiota are the most important nonantibiotic targets to combat CDI. This report outlines these targets and how they could become the focus of future therapeutic agents. Inhibiting colonization and virulence factors during CDI will disrupt pathogen persistence and decrease exposure to the inflammatory toxins, allowing the immune system to clear the infection." @default.
- W2740961745 created "2017-08-08" @default.
- W2740961745 creator A5022890061 @default.
- W2740961745 creator A5024498021 @default.
- W2740961745 creator A5067231627 @default.
- W2740961745 date "2017-09-01" @default.
- W2740961745 modified "2023-10-02" @default.
- W2740961745 title "Nonantimicrobial drug targets for <i>Clostridium difficile</i> infections" @default.
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- W2740961745 doi "https://doi.org/10.2217/fmb-2017-0024" @default.
- W2740961745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5618939" @default.
- W2740961745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28759258" @default.
- W2740961745 hasPublicationYear "2017" @default.
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