Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741076111> ?p ?o ?g. }
- W2741076111 endingPage "894" @default.
- W2741076111 startingPage "884" @default.
- W2741076111 abstract "The circulatory system distributes blood flow to each tissue and transports oxygen and nutrients. Peripheral circulation is required to maintain the physiological function in each tissue. Disturbance of circulation, therefore, decreases oxygen delivery, leading to tissue hypoxia which takes place in several cardiovascular disorders including atherosclerosis, pulmonary arterial hypertension and heart failure. While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate tissue remodeling processes or the severity of the cardiovascular disorders. Hypoxia inducible factor-1α (HIF-1α) and HIF-2α belongs to a group of transcription factors which mediate most of the cellular responses to hypoxia at a transcriptional level. We, and others, have reported that HIF-α signaling plays a critical role in the initiation or the regulation of inflammation. HIF-α signaling contributes to the tissue remodeling processes; thus it has a potential to become a therapeutic target. Elucidation of the molecular link, therefore, between hypoxia signaling and tissue remodeling will greatly help us to understand the pathophysiology of the cardiovascular disorders. The purpose of this review is to give a brief overview of the current understanding about the function HIF-α in inflammation processes especially by focusing on its roles in macrophages. In addition, the pathophysiological roles of hypoxia signaling for the development of cardiovascular disease will be discussed." @default.
- W2741076111 created "2017-08-08" @default.
- W2741076111 creator A5000377104 @default.
- W2741076111 creator A5078585781 @default.
- W2741076111 creator A5085510590 @default.
- W2741076111 date "2017-01-01" @default.
- W2741076111 modified "2023-10-16" @default.
- W2741076111 title "The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases" @default.
- W2741076111 cites W1607375821 @default.
- W2741076111 cites W1749022239 @default.
- W2741076111 cites W1857052429 @default.
- W2741076111 cites W1860424934 @default.
- W2741076111 cites W1906027219 @default.
- W2741076111 cites W1969734439 @default.
- W2741076111 cites W1971530727 @default.
- W2741076111 cites W1972899667 @default.
- W2741076111 cites W1976329823 @default.
- W2741076111 cites W1978525637 @default.
- W2741076111 cites W1979036898 @default.
- W2741076111 cites W1980468558 @default.
- W2741076111 cites W1981253971 @default.
- W2741076111 cites W1984235771 @default.
- W2741076111 cites W1987846826 @default.
- W2741076111 cites W1990253071 @default.
- W2741076111 cites W1990286868 @default.
- W2741076111 cites W1992866141 @default.
- W2741076111 cites W1998361432 @default.
- W2741076111 cites W1999630001 @default.
- W2741076111 cites W2000075945 @default.
- W2741076111 cites W2006958729 @default.
- W2741076111 cites W2010503509 @default.
- W2741076111 cites W2010592415 @default.
- W2741076111 cites W2013243629 @default.
- W2741076111 cites W2018183883 @default.
- W2741076111 cites W2026469629 @default.
- W2741076111 cites W2027415008 @default.
- W2741076111 cites W2029684799 @default.
- W2741076111 cites W2033486658 @default.
- W2741076111 cites W2033803279 @default.
- W2741076111 cites W2033958147 @default.
- W2741076111 cites W2036632357 @default.
- W2741076111 cites W2038046576 @default.
- W2741076111 cites W2038461328 @default.
- W2741076111 cites W2038634187 @default.
- W2741076111 cites W2038689279 @default.
- W2741076111 cites W2048667506 @default.
- W2741076111 cites W2051088765 @default.
- W2741076111 cites W2052780003 @default.
- W2741076111 cites W2054472394 @default.
- W2741076111 cites W2056717322 @default.
- W2741076111 cites W2056786396 @default.
- W2741076111 cites W2066885413 @default.
- W2741076111 cites W2066963386 @default.
- W2741076111 cites W2068984983 @default.
- W2741076111 cites W2070236131 @default.
- W2741076111 cites W2071293996 @default.
- W2741076111 cites W2072727898 @default.
- W2741076111 cites W2072839085 @default.
- W2741076111 cites W2076396596 @default.
- W2741076111 cites W2077688443 @default.
- W2741076111 cites W2081023211 @default.
- W2741076111 cites W2082578363 @default.
- W2741076111 cites W2092266379 @default.
- W2741076111 cites W2093236829 @default.
- W2741076111 cites W2093579776 @default.
- W2741076111 cites W2093705034 @default.
- W2741076111 cites W2097722794 @default.
- W2741076111 cites W2101084498 @default.
- W2741076111 cites W2101569046 @default.
- W2741076111 cites W2102476325 @default.
- W2741076111 cites W2104179458 @default.
- W2741076111 cites W2106925175 @default.
- W2741076111 cites W2112648300 @default.
- W2741076111 cites W2116732368 @default.
- W2741076111 cites W2122515902 @default.
- W2741076111 cites W2124009251 @default.
- W2741076111 cites W2128722360 @default.
- W2741076111 cites W2129367108 @default.
- W2741076111 cites W2130576870 @default.
- W2741076111 cites W2135647797 @default.
- W2741076111 cites W2135836641 @default.
- W2741076111 cites W2145602685 @default.
- W2741076111 cites W2147155927 @default.
- W2741076111 cites W2149472502 @default.
- W2741076111 cites W2153914310 @default.
- W2741076111 cites W2155206333 @default.
- W2741076111 cites W2157601642 @default.
- W2741076111 cites W2157758580 @default.
- W2741076111 cites W2159513257 @default.
- W2741076111 cites W2162121911 @default.
- W2741076111 cites W2163293935 @default.
- W2741076111 cites W2163531020 @default.
- W2741076111 cites W2167251312 @default.
- W2741076111 cites W2171056569 @default.
- W2741076111 cites W2181241483 @default.
- W2741076111 cites W2324476825 @default.
- W2741076111 cites W2389798666 @default.
- W2741076111 cites W2403326267 @default.