FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741091925> ?p ?o ?g. }

• W2741091925 abstract "Liver Kinase B1 (LKB1), encoded by STK11, is a tumor suppressor and somatically mutated in approximately 20% of lung adenocarcinoma. Aside from the effects of LKB1 inactivation on tumor initiation, LKB1-mutant cancers are biologically distinct from cancer with functional LKB1, and the loss of LKB1 uniquely confers invasive and metastatic properties in genetically engineered mouse models of cancer. While various pathways, including energy metabolism, cell polarity, and cell growth, are regulated by LKB1 and can play a pleiotropic role in cancer initiation and progression, no therapies are currently available for clinical use that specifically target LKB1 inactivation. Therefore, elucidation of the functional mechanisms associated with LKB1 inactivation has translational relevance. We analyzed proteomic profiles of 45 lung adenocarcinoma cell lines with and without LKB1 inactivation to identify molecular features associated with LKB1 inactivation. Carbamoyl phosphate synthase 1 (CPS1) was identified as a markedly overexpressed protein in LKB1-inactivated lung adenocarcinoma cell lines. CPS1 is the first rate-limiting mitochondrial enzyme in the urea cycle, and plays an intricate role in arginine and pyrimidine metabolism. CPS1 knockdown reduced cell growth, decreased levels of metabolites associated with nucleic acid biosynthesis pathway, and contributed an additive effect when combined with conventional chemotherapy agents including gemcitabine, pemetrexed, or CHK1 inhibitor AZD7762. Tissue microarray analysis using 305 lung adenocarcinoma tumors revealed that CPS1 was expressed in 65.7% of LKB1-negative and only 5.0% of LKB1-positive lung adenocarcinomas. In addition, CPS1 expression was significantly and independently associated with poor overall survival of lung adenocarcinoma patients (P Citation Format: Muge Celiktas, Ichidai Tanaka, Satyendra Chandra Tripathi, Johannes F. Fahrmann, Clemente Aguilar-Bonavides, Pamela Villalobos, Oliver Delgado, Dilsher Dhillon, Jennifer B. Dennison, Edwin J. Ostrin, Hong Wang, Carmen Behrens, Kim-Anh Do, Adi F. Gazdar, Samir M. Hanash, Ayumu Taguchi. CPS1 as a therapeutic target and prognostic indicator in LKB1-inactivated lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2775. doi:10.1158/1538-7445.AM2017-2775" @default.
• W2741091925 created "2017-08-08" @default.
• W2741091925 creator A5000796870 @default.
• W2741091925 creator A5005514003 @default.
• W2741091925 creator A5009105122 @default.
• W2741091925 creator A5018231034 @default.
• W2741091925 creator A5033020983 @default.
• W2741091925 creator A5033841777 @default.
• W2741091925 creator A5040156444 @default.
• W2741091925 creator A5046112171 @default.
• W2741091925 creator A5048679191 @default.
• W2741091925 creator A5050198314 @default.
• W2741091925 creator A5055265122 @default.
• W2741091925 creator A5059166265 @default.
• W2741091925 creator A5070211012 @default.
• W2741091925 creator A5072417435 @default.
• W2741091925 creator A5072596013 @default.
• W2741091925 creator A5081331298 @default.
• W2741091925 date "2017-07-01" @default.
• W2741091925 modified "2023-09-27" @default.
• W2741091925 title "Abstract 2775: CPS1 as a therapeutic target and prognostic indicator in LKB1-inactivated lung adenocarcinoma" @default.
• W2741091925 doi "https://doi.org/10.1158/1538-7445.am2017-2775" @default.
• W2741091925 hasPublicationYear "2017" @default.
• W2741091925 type Work @default.
• W2741091925 sameAs 2741091925 @default.
• W2741091925 citedByCount "0" @default.
• W2741091925 crossrefType "proceedings-article" @default.
• W2741091925 hasAuthorship W2741091925A5000796870 @default.
• W2741091925 hasAuthorship W2741091925A5005514003 @default.
• W2741091925 hasAuthorship W2741091925A5009105122 @default.
• W2741091925 hasAuthorship W2741091925A5018231034 @default.
• W2741091925 hasAuthorship W2741091925A5033020983 @default.
• W2741091925 hasAuthorship W2741091925A5033841777 @default.
• W2741091925 hasAuthorship W2741091925A5040156444 @default.
• W2741091925 hasAuthorship W2741091925A5046112171 @default.
• W2741091925 hasAuthorship W2741091925A5048679191 @default.
• W2741091925 hasAuthorship W2741091925A5050198314 @default.
• W2741091925 hasAuthorship W2741091925A5055265122 @default.
• W2741091925 hasAuthorship W2741091925A5059166265 @default.
• W2741091925 hasAuthorship W2741091925A5070211012 @default.
• W2741091925 hasAuthorship W2741091925A5072417435 @default.
• W2741091925 hasAuthorship W2741091925A5072596013 @default.
• W2741091925 hasAuthorship W2741091925A5081331298 @default.
• W2741091925 hasConcept C121608353 @default.
• W2741091925 hasConcept C142724271 @default.
• W2741091925 hasConcept C184235292 @default.
• W2741091925 hasConcept C2776232967 @default.
• W2741091925 hasConcept C2776256026 @default.
• W2741091925 hasConcept C2776694085 @default.
• W2741091925 hasConcept C2777240266 @default.
• W2741091925 hasConcept C2778239845 @default.
• W2741091925 hasConcept C2779422266 @default.
• W2741091925 hasConcept C2780258809 @default.
• W2741091925 hasConcept C2781182431 @default.
• W2741091925 hasConcept C502942594 @default.
• W2741091925 hasConcept C54355233 @default.
• W2741091925 hasConcept C55493867 @default.
• W2741091925 hasConcept C71924100 @default.
• W2741091925 hasConcept C86803240 @default.
• W2741091925 hasConceptScore W2741091925C121608353 @default.
• W2741091925 hasConceptScore W2741091925C142724271 @default.
• W2741091925 hasConceptScore W2741091925C184235292 @default.
• W2741091925 hasConceptScore W2741091925C2776232967 @default.
• W2741091925 hasConceptScore W2741091925C2776256026 @default.
• W2741091925 hasConceptScore W2741091925C2776694085 @default.
• W2741091925 hasConceptScore W2741091925C2777240266 @default.
• W2741091925 hasConceptScore W2741091925C2778239845 @default.
• W2741091925 hasConceptScore W2741091925C2779422266 @default.
• W2741091925 hasConceptScore W2741091925C2780258809 @default.
• W2741091925 hasConceptScore W2741091925C2781182431 @default.
• W2741091925 hasConceptScore W2741091925C502942594 @default.
• W2741091925 hasConceptScore W2741091925C54355233 @default.
• W2741091925 hasConceptScore W2741091925C55493867 @default.
• W2741091925 hasConceptScore W2741091925C71924100 @default.
• W2741091925 hasConceptScore W2741091925C86803240 @default.
• W2741091925 hasLocation W27410919251 @default.
• W2741091925 hasOpenAccess W2741091925 @default.
• W2741091925 hasPrimaryLocation W27410919251 @default.
• W2741091925 hasRelatedWork W1551648980 @default.
• W2741091925 hasRelatedWork W1613000489 @default.
• W2741091925 hasRelatedWork W1963678202 @default.
• W2741091925 hasRelatedWork W2070736788 @default.
• W2741091925 hasRelatedWork W2287692243 @default.
• W2741091925 hasRelatedWork W2325532963 @default.
• W2741091925 hasRelatedWork W2328159682 @default.
• W2741091925 hasRelatedWork W2479190467 @default.
• W2741091925 hasRelatedWork W2480270932 @default.
• W2741091925 hasRelatedWork W2563962027 @default.
• W2741091925 hasRelatedWork W2620975370 @default.
• W2741091925 hasRelatedWork W2738617126 @default.
• W2741091925 hasRelatedWork W2811278802 @default.
• W2741091925 hasRelatedWork W2884480429 @default.
• W2741091925 hasRelatedWork W2885677664 @default.
• W2741091925 hasRelatedWork W2887518846 @default.
• W2741091925 hasRelatedWork W3082880931 @default.
• W2741091925 hasRelatedWork W3153612203 @default.
• W2741091925 hasRelatedWork W3178287842 @default.
• W2741091925 hasRelatedWork W3206548099 @default.
• W2741091925 isParatext "false" @default.
• W2741091925 isRetracted "false" @default.

• next