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- W274112427 abstract "Abstract : This project utilized the zinc enzyme human carbonic anhydrase II (CAII) as a paradigm for dissecting and understanding the structural basis of protein-transition metal recognition and discrimination. We have successfully redesigned the zinc binding site of CAII so that protein-metal affinity can be modulated by design, by factors of 10 from micromolar to femtomolar affinity. We have explored the binding of zinc and copper to engineered CAIIs using high resolution X-ray crystallographic methods, and we have developed a zinc-sensing scheme using fluorescence anisotropy and a designed sulfonamide inhibitor." @default.
- W274112427 created "2016-06-24" @default.
- W274112427 creator A5015579596 @default.
- W274112427 date "1998-06-30" @default.
- W274112427 modified "2023-09-23" @default.
- W274112427 title "Structural Aspects of Protein-Metal Recognition and Discrimination." @default.
- W274112427 doi "https://doi.org/10.21236/ada360597" @default.
- W274112427 hasPublicationYear "1998" @default.
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