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• W2741127930 abstract "Natural Saccharomyces strains isolated from the wild differ quantitatively in molecular and organismal phenotypes. Quantitative trait loci (QTL) mapping is a powerful approach for identifying sequence variants that alter gene function. In yeast, QTL mapping has been used in designed crosses to map functional polymorphisms. This approach, outlined here, is often the first step in understanding the molecular basis of quantitative traits. New large-scale sequencing surveys have the potential to directly associate genotypes with organismal phenotypes, providing a broader catalog of causative genetic variants. Additional analysis of intermediate phenotypes (e.g., RNA, protein, or metabolite levels) can produce a multilayered and integrated view of individual variation, producing a high-resolution view of the genotype–phenotype map." @default.
• W2741127930 created "2017-08-08" @default.
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• W2741127930 date "2017-08-01" @default.
• W2741127930 modified "2023-09-25" @default.
• W2741127930 title "Mapping Quantitative Trait Loci in Yeast" @default.
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• W2741127930 doi "https://doi.org/10.1101/pdb.prot089060" @default.
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