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- W2741237687 abstract "3 Abstract: In the present study we investigated the effect of both methanolic extract and cuttlebone of Sepia officinalis against sepsis induced by cecal ligation and puncture CLP in rats. 48 male albino rats were divided into four groups. Group I Sham control rats. Group II CLP model (septic rats). Group III Septic rats treated with body tissue extract of sepia 200mg/kg body weight, one dose daily for seven days. Group IV Septic rats treated with cuttlebone extract 200mg/kg body weight, one dose daily for seven days. It was found that CLP models lead to histopathological changes in the lung characterized by interstitial pneumonia, the kidney showed atrophy of glomerular tuft and congestion of renal blood vessel, the testis showed degeneration of spermatogoneal cells. Group III showed mild histopathological changes. Group I and group IV rats showed no histopathological changes.The immunohistochemical staining of caspase-3 in studied organs showed strong immunopositive reaction in CLP group, mild immunopositivity in Group III, while group I and group IV rats showed no expression of caspase-3. In conclusion, the current study indicated that the body tissue extract of Sepia had a mild antiseptic effect against sepsis while its cuttlebone showed strong antiseptic effect." @default.
- W2741237687 created "2017-08-08" @default.
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- W2741237687 date "2015-01-01" @default.
- W2741237687 modified "2023-09-25" @default.
- W2741237687 title "Histopathological and Immunohistochemical Studies of Antiseptic Effect of Sepia officinalis Against Induced Sepsis in Male Albino Rats (Rattus norvegicus)" @default.
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