FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741247405> ?p ?o ?g. }

• W2741247405 endingPage "e0182175" @default.
• W2741247405 startingPage "e0182175" @default.
• W2741247405 abstract "Whereas transformation events in hematopoietic malignancies may occur at different developmental stages, the initial mutation originates in hematopoietic stem cells (HSCs), creating a preleukemic stem cell (PLSC). Subsequent mutations at either stem cell or progenitor cell levels transform the PLSC into lymphoma/leukemia initiating cells (LIC). Thymic lymphomas have been thought to develop from developing thymocytes. T cell progenitors are generated from HSCs in the bone marrow (BM), but maturation and proliferation of T cells as well as T-lymphomagenesis depends on both regulatory mechanisms and microenvironment within the thymus. We studied PLSC linked to thymic lymphomas. In this study, we use MSH2-/- mice as a model to investigate the existence of PLSC and the evolution of PLSC to LIC. Following BM transplantation, we found that MSH2-/- BM cells from young mice are able to fully reconstitute multiple hematopoietic lineages of lethally irradiated wild-type recipients. However, all recipients developed thymic lymphomas within three and four months post transplantation. Transplantation of different fractions of BM cells or thymocytes from young health MSH2-/- mice showed that an HSC enriched fraction always reconstituted hematopoiesis followed by lymphoma development. In addition, lymphomas did not occur in thymectomized recipients of MSH2-/- BM. These results suggest that HSCs with DNA repair defects such as MSH2-/- are PLSCs because they retain hematopoietic function, but also carry an obligate lymphomagenic potential within their T-cell progeny that is dependent on the thymic microenvironment." @default.
• W2741247405 created "2017-08-08" @default.
• W2741247405 creator A5019470085 @default.
• W2741247405 creator A5039097660 @default.
• W2741247405 date "2017-08-02" @default.
• W2741247405 modified "2023-09-25" @default.
• W2741247405 title "Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells" @default.
• W2741247405 cites W1719320996 @default.
• W2741247405 cites W1967205646 @default.
• W2741247405 cites W1968121660 @default.
• W2741247405 cites W1972730151 @default.
• W2741247405 cites W1977048390 @default.
• W2741247405 cites W1977284533 @default.
• W2741247405 cites W1979448919 @default.
• W2741247405 cites W1983306073 @default.
• W2741247405 cites W1994988780 @default.
• W2741247405 cites W1997383526 @default.
• W2741247405 cites W1998787430 @default.
• W2741247405 cites W2007968891 @default.
• W2741247405 cites W2009886857 @default.
• W2741247405 cites W2018699730 @default.
• W2741247405 cites W2020522324 @default.
• W2741247405 cites W2025891700 @default.
• W2741247405 cites W2032406291 @default.
• W2741247405 cites W2037898576 @default.
• W2741247405 cites W2052155366 @default.
• W2741247405 cites W2053827853 @default.
• W2741247405 cites W2061512954 @default.
• W2741247405 cites W2062082839 @default.
• W2741247405 cites W2063124444 @default.
• W2741247405 cites W2068622682 @default.
• W2741247405 cites W2070569107 @default.
• W2741247405 cites W2076031927 @default.
• W2741247405 cites W2077059059 @default.
• W2741247405 cites W2085843470 @default.
• W2741247405 cites W2090786449 @default.
• W2741247405 cites W2097519948 @default.
• W2741247405 cites W2099769239 @default.
• W2741247405 cites W2133406385 @default.
• W2741247405 cites W2135447662 @default.
• W2741247405 cites W2139310798 @default.
• W2741247405 cites W2143828280 @default.
• W2741247405 cites W2148965443 @default.
• W2741247405 cites W2152414109 @default.
• W2741247405 cites W2161143642 @default.
• W2741247405 cites W2206735890 @default.
• W2741247405 cites W2271533528 @default.
• W2741247405 cites W2289907581 @default.
• W2741247405 cites W2312674677 @default.
• W2741247405 cites W2313108953 @default.
• W2741247405 cites W2419627211 @default.
• W2741247405 cites W266334352 @default.
• W2741247405 cites W4244972941 @default.
• W2741247405 cites W78334516 @default.
• W2741247405 doi "https://doi.org/10.1371/journal.pone.0182175" @default.
• W2741247405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5540588" @default.
• W2741247405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28767666" @default.
• W2741247405 hasPublicationYear "2017" @default.
• W2741247405 type Work @default.
• W2741247405 sameAs 2741247405 @default.
• W2741247405 citedByCount "4" @default.
• W2741247405 countsByYear W27412474052017 @default.
• W2741247405 countsByYear W27412474052018 @default.
• W2741247405 countsByYear W27412474052019 @default.
• W2741247405 crossrefType "journal-article" @default.
• W2741247405 hasAuthorship W2741247405A5019470085 @default.
• W2741247405 hasAuthorship W2741247405A5039097660 @default.
• W2741247405 hasBestOaLocation W27412474051 @default.
• W2741247405 hasConcept C109159458 @default.
• W2741247405 hasConcept C126322002 @default.
• W2741247405 hasConcept C201750760 @default.
• W2741247405 hasConcept C2022786 @default.
• W2741247405 hasConcept C203014093 @default.
• W2741247405 hasConcept C2778461978 @default.
• W2741247405 hasConcept C2779338263 @default.
• W2741247405 hasConcept C2780007613 @default.
• W2741247405 hasConcept C28328180 @default.
• W2741247405 hasConcept C2911091166 @default.
• W2741247405 hasConcept C502942594 @default.
• W2741247405 hasConcept C71924100 @default.
• W2741247405 hasConcept C86803240 @default.
• W2741247405 hasConcept C95444343 @default.
• W2741247405 hasConceptScore W2741247405C109159458 @default.
• W2741247405 hasConceptScore W2741247405C126322002 @default.
• W2741247405 hasConceptScore W2741247405C201750760 @default.
• W2741247405 hasConceptScore W2741247405C2022786 @default.
• W2741247405 hasConceptScore W2741247405C203014093 @default.
• W2741247405 hasConceptScore W2741247405C2778461978 @default.
• W2741247405 hasConceptScore W2741247405C2779338263 @default.
• W2741247405 hasConceptScore W2741247405C2780007613 @default.
• W2741247405 hasConceptScore W2741247405C28328180 @default.
• W2741247405 hasConceptScore W2741247405C2911091166 @default.
• W2741247405 hasConceptScore W2741247405C502942594 @default.
• W2741247405 hasConceptScore W2741247405C71924100 @default.
• W2741247405 hasConceptScore W2741247405C86803240 @default.
• W2741247405 hasConceptScore W2741247405C95444343 @default.
• W2741247405 hasFunder F4320332161 @default.
• W2741247405 hasIssue "8" @default.

• next