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• W2741258345 abstract "Abstract Objective. – A one-year prospective, observational study was conducted in the west of France, to evaluate the epidemiology of candidemia. Method.– During the year 2004, each patient with at least one blood culture yielding Candida sp. was included. For each episode of candidemia,mycological, demographical, clinical, and therapeutic data, as well as outcome, were collected. Results. – One hundred and ninety-three strains of Candida sp. were isolated in 186 patients, Candidaalbicans accounting for 54.9%, Can-didaglabrata for 18.7%, Candidaparapsilosis for 12.9%, Candidatropicalis for 4.7% and Candidakrusei for 4.1% of these isolates. A percentageof 84% of the Candida isolates were fully susceptible to fluconazole in vitro. Dose-dependent susceptibility or resistance to fluconazole wasdetected in more than one third of the Candidaglabrata strains, of which 36% were also resistant to voriconazole. Two-thirds of the patients weremales, and the mean age was 61.5 years. A percentage of 37% of patients were hospitalized in intensive care units. The main predisposing factorsfor candidemia were broad-spectrum antibiotics (75.8%), central venous catheter (72.6%), cancer or hematologic malignancy (47.3%), recentsurgery (42.5%), total parenteral nutrition (37.6%). One hundred and fifty-four patients were treated with antifungal therapy, two-thirds of whomreceived fluconazole as first-line agent. Mortality was 49% overall, and was significantly higher in case of septic shock, advanced age, and absenceof catheter removal.© 2009 Elsevier Masson SAS. All rights reserved." @default.
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• W2741258345 date "2009-01-01" @default.
• W2741258345 modified "2023-09-24" @default.
• W2741258345 title "Épidémiologie des candidémies : étude observationnelle prospective d'un an dans l'Ouest de la France Epidemiology of candidemia: A one-year prospective observational study in the west of France" @default.
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