FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741318621> ?p ?o ?g. }

• W2741318621 abstract "The critical roles of inflammation in the development of cancer have long been appreciated. A growing body of evidence supports the notion that infiltrates of inflammatory cells into tumor microenvironment influence the tumor progression by providing bioactive molecules including pro-inflammatory cytokines. Importantly, the increased number of mast cells within tumor microenvironment has been associated with a poor survival in cancer patients. Moreover, keratinocyte inflammation is known to be crucial for skin tumor development. The use of natural products to reduce inflammation in tumor microenvironment is gaining an interest, because of their reduced toxicity toward normal cells. In this study, we tested the effects of Tonggyu-tang (TGT) which is composed of 14 different herbal extracts on the activity of mast cells. We found that TGT significantly reduced the expression and production of inflammatory cytokines such as IL-4, IL-6, IL-8, and TNF-α in PMA and ionomycin- stimulated HMC-1 (human mast cell line-1). In an attempt to determine molecular mechanism underlying the inhibitory effects of TGT on cytokine expression, we revealed that TGT suppressed MAPK signaling pathway including ERK, p38, and JNK as well as NF-κB pathway, which are known to regulate inflammatory cytokine expression. Similar results were obtained from the LPS-stimulated HaCaT cells, immortalized human keratinocytes. Taken together, our results demonstrate that TGT suppresses inflammation by inhibiting the expression of pro-inflammatory cytokine in both mast cells and keratinocytes, thereby potentially leading to inhibition of tumor progression. Citation Format: Hyoin Kim, Seong-Gyu Ko, Yong Cheol Shin, Ji Hye Kim, Hye-Sook Seo, Tai Young Kim, Se Hyang Hong, Kangwook Lee, Jin Mo Ku, Myeong-Sun Kim, Yu-Jeong Choi, Soo-yeon Kang, Chunhoo Cheon, Youme Ko, Huang Ching Wen, Yui Sasaki, Sohyeon Kang. Tonggyu-tang, a traditional Korean medicine, suppresses inflammation, potential implications in tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4010. doi:10.1158/1538-7445.AM2017-4010" @default.
• W2741318621 created "2017-08-08" @default.
• W2741318621 creator A5011068004 @default.
• W2741318621 creator A5021601601 @default.
• W2741318621 creator A5035698153 @default.
• W2741318621 creator A5040511774 @default.
• W2741318621 creator A5041462196 @default.
• W2741318621 creator A5049362745 @default.
• W2741318621 creator A5050764023 @default.
• W2741318621 creator A5051542279 @default.
• W2741318621 creator A5057357359 @default.
• W2741318621 creator A5058202763 @default.
• W2741318621 creator A5067403847 @default.
• W2741318621 creator A5068284030 @default.
• W2741318621 creator A5073193050 @default.
• W2741318621 creator A5074067628 @default.
• W2741318621 creator A5077375059 @default.
• W2741318621 creator A5089641474 @default.
• W2741318621 creator A5090146496 @default.
• W2741318621 date "2017-07-01" @default.
• W2741318621 modified "2023-09-27" @default.
• W2741318621 title "Abstract 4010: Tonggyu-tang, a traditional Korean medicine, suppresses inflammation, potential implications in tumor microenvironment" @default.
• W2741318621 doi "https://doi.org/10.1158/1538-7445.am2017-4010" @default.
• W2741318621 hasPublicationYear "2017" @default.
• W2741318621 type Work @default.
• W2741318621 sameAs 2741318621 @default.
• W2741318621 citedByCount "0" @default.
• W2741318621 crossrefType "proceedings-article" @default.
• W2741318621 hasAuthorship W2741318621A5011068004 @default.
• W2741318621 hasAuthorship W2741318621A5021601601 @default.
• W2741318621 hasAuthorship W2741318621A5035698153 @default.
• W2741318621 hasAuthorship W2741318621A5040511774 @default.
• W2741318621 hasAuthorship W2741318621A5041462196 @default.
• W2741318621 hasAuthorship W2741318621A5049362745 @default.
• W2741318621 hasAuthorship W2741318621A5050764023 @default.
• W2741318621 hasAuthorship W2741318621A5051542279 @default.
• W2741318621 hasAuthorship W2741318621A5057357359 @default.
• W2741318621 hasAuthorship W2741318621A5058202763 @default.
• W2741318621 hasAuthorship W2741318621A5067403847 @default.
• W2741318621 hasAuthorship W2741318621A5068284030 @default.
• W2741318621 hasAuthorship W2741318621A5073193050 @default.
• W2741318621 hasAuthorship W2741318621A5074067628 @default.
• W2741318621 hasAuthorship W2741318621A5077375059 @default.
• W2741318621 hasAuthorship W2741318621A5089641474 @default.
• W2741318621 hasAuthorship W2741318621A5090146496 @default.
• W2741318621 hasConcept C118995209 @default.
• W2741318621 hasConcept C121608353 @default.
• W2741318621 hasConcept C126322002 @default.
• W2741318621 hasConcept C164027704 @default.
• W2741318621 hasConcept C17991360 @default.
• W2741318621 hasConcept C185592680 @default.
• W2741318621 hasConcept C203014093 @default.
• W2741318621 hasConcept C2776107976 @default.
• W2741318621 hasConcept C2776914184 @default.
• W2741318621 hasConcept C2778690821 @default.
• W2741318621 hasConcept C2779256057 @default.
• W2741318621 hasConcept C502942594 @default.
• W2741318621 hasConcept C51551487 @default.
• W2741318621 hasConcept C54355233 @default.
• W2741318621 hasConcept C57074206 @default.
• W2741318621 hasConcept C62478195 @default.
• W2741318621 hasConcept C71924100 @default.
• W2741318621 hasConcept C81885089 @default.
• W2741318621 hasConcept C86803240 @default.
• W2741318621 hasConcept C8891405 @default.
• W2741318621 hasConcept C95444343 @default.
• W2741318621 hasConceptScore W2741318621C118995209 @default.
• W2741318621 hasConceptScore W2741318621C121608353 @default.
• W2741318621 hasConceptScore W2741318621C126322002 @default.
• W2741318621 hasConceptScore W2741318621C164027704 @default.
• W2741318621 hasConceptScore W2741318621C17991360 @default.
• W2741318621 hasConceptScore W2741318621C185592680 @default.
• W2741318621 hasConceptScore W2741318621C203014093 @default.
• W2741318621 hasConceptScore W2741318621C2776107976 @default.
• W2741318621 hasConceptScore W2741318621C2776914184 @default.
• W2741318621 hasConceptScore W2741318621C2778690821 @default.
• W2741318621 hasConceptScore W2741318621C2779256057 @default.
• W2741318621 hasConceptScore W2741318621C502942594 @default.
• W2741318621 hasConceptScore W2741318621C51551487 @default.
• W2741318621 hasConceptScore W2741318621C54355233 @default.
• W2741318621 hasConceptScore W2741318621C57074206 @default.
• W2741318621 hasConceptScore W2741318621C62478195 @default.
• W2741318621 hasConceptScore W2741318621C71924100 @default.
• W2741318621 hasConceptScore W2741318621C81885089 @default.
• W2741318621 hasConceptScore W2741318621C86803240 @default.
• W2741318621 hasConceptScore W2741318621C8891405 @default.
• W2741318621 hasConceptScore W2741318621C95444343 @default.
• W2741318621 hasLocation W27413186211 @default.
• W2741318621 hasOpenAccess W2741318621 @default.
• W2741318621 hasPrimaryLocation W27413186211 @default.
• W2741318621 hasRelatedWork W1748818950 @default.
• W2741318621 hasRelatedWork W1970873290 @default.
• W2741318621 hasRelatedWork W1971480406 @default.
• W2741318621 hasRelatedWork W1987376846 @default.
• W2741318621 hasRelatedWork W2006574963 @default.
• W2741318621 hasRelatedWork W2014644900 @default.
• W2741318621 hasRelatedWork W2282884512 @default.
• W2741318621 hasRelatedWork W2320212744 @default.
• W2741318621 hasRelatedWork W2327442586 @default.
• W2741318621 hasRelatedWork W2514386944 @default.

• next