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- W2741340281 abstract "Infection with JHMV results in the transcriptional activation of two host cell genes encoding pro inflammatory cytokines, tumor necrosis factor (TNF)-a and interleukin (IL) IP, Analysis of irradiated mice showed that IL- IP mRNA accumulation in the central nervous system was predominantly derived from the mononuclear infiltrate. By contrast, accumulation of TNF-a mRNA was unaffected by immunosuppression, suggesting that resident cells were the source of this cytokine. Infected mice were treated with anti-TNF antibody to determine ifTNF-a contributed to either the encephalomyelitis or demyelination associated with JHMV infection. Surprisingly, neither the cellular infiltrate nor demyelina tion were affected. In vitro analysis showed that IL-I P but not TNF was secreted from JHMV infected macrophages. The absence of TNF secretion is due to a block in translation of the TNF mRNA which accumulates during infection." @default.
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- W2741340281 date "1995-01-01" @default.
- W2741340281 modified "2023-09-24" @default.
- W2741340281 title "TRANSCRIPTION AND TRANSLATION OF PRO INFLAMMATORY CYTOKINES FOLLOWING JHMV INFECTION" @default.
- W2741340281 hasPublicationYear "1995" @default.
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