Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741346324> ?p ?o ?g. }
- W2741346324 endingPage "1889" @default.
- W2741346324 startingPage "1884" @default.
- W2741346324 abstract "Over the past decade, ankyrin-B has been identified as a prominent player in cardiac physiology. Ankyrin-B has a multitude of functions, with roles in expression, localization, and regulation of proteins critical for cardiac excitability, cytoskeletal integrity, and signaling. Furthermore, human ANK2 variants that result in ankyrin-B loss of function are associated with ankyrin-B syndrome, a complex cardiac phenotype that may include bradycardia and heart rate variability, conduction block, atrial fibrillation, QT interval prolongation, and potentially fatal catecholaminergic polymorphic ventricular tachycardia. However, our understanding of the molecular mechanisms underlying ankyrin-B function at baseline and in disease is still not fully developed owing to the complexity of ankyrin-B gene regulation, number of ankyrin-B-associated molecules, multiple roles of ankyrin-B in the heart and other organs that modulate cardiac function, and a host of unexpected clinical phenotypes. In this review, we summarize known roles of ankyrin-B in the heart and the impact of ankyrin-B dysfunction in animal models and in human disease as well as highlight important new findings illustrating the complexity of ankyrin-B signaling." @default.
- W2741346324 created "2017-08-08" @default.
- W2741346324 creator A5048118890 @default.
- W2741346324 creator A5084060067 @default.
- W2741346324 date "2017-12-01" @default.
- W2741346324 modified "2023-09-26" @default.
- W2741346324 title "The evolving role of ankyrin-B in cardiovascular disease" @default.
- W2741346324 cites W1492909811 @default.
- W2741346324 cites W1521731378 @default.
- W2741346324 cites W1606121092 @default.
- W2741346324 cites W1961755849 @default.
- W2741346324 cites W1969961716 @default.
- W2741346324 cites W1971203163 @default.
- W2741346324 cites W1983012115 @default.
- W2741346324 cites W1983904562 @default.
- W2741346324 cites W1988855682 @default.
- W2741346324 cites W1996156433 @default.
- W2741346324 cites W1999961275 @default.
- W2741346324 cites W2003504970 @default.
- W2741346324 cites W2003582994 @default.
- W2741346324 cites W2005772990 @default.
- W2741346324 cites W2009991646 @default.
- W2741346324 cites W2021597262 @default.
- W2741346324 cites W2021958603 @default.
- W2741346324 cites W2022379266 @default.
- W2741346324 cites W2022526409 @default.
- W2741346324 cites W2025679166 @default.
- W2741346324 cites W2030550346 @default.
- W2741346324 cites W2031638273 @default.
- W2741346324 cites W2035801011 @default.
- W2741346324 cites W2036097053 @default.
- W2741346324 cites W2036577601 @default.
- W2741346324 cites W2041897339 @default.
- W2741346324 cites W2042646075 @default.
- W2741346324 cites W2043174693 @default.
- W2741346324 cites W2043673493 @default.
- W2741346324 cites W2050824263 @default.
- W2741346324 cites W2051543771 @default.
- W2741346324 cites W2051822015 @default.
- W2741346324 cites W2055764374 @default.
- W2741346324 cites W2057262768 @default.
- W2741346324 cites W2061686154 @default.
- W2741346324 cites W2064605612 @default.
- W2741346324 cites W2067307702 @default.
- W2741346324 cites W2069909801 @default.
- W2741346324 cites W2080397790 @default.
- W2741346324 cites W2081186536 @default.
- W2741346324 cites W2081867103 @default.
- W2741346324 cites W2083300468 @default.
- W2741346324 cites W2088131585 @default.
- W2741346324 cites W2093753283 @default.
- W2741346324 cites W2096875864 @default.
- W2741346324 cites W2097436210 @default.
- W2741346324 cites W2100024219 @default.
- W2741346324 cites W2100209313 @default.
- W2741346324 cites W2100782276 @default.
- W2741346324 cites W2103154455 @default.
- W2741346324 cites W2108376995 @default.
- W2741346324 cites W2108608061 @default.
- W2741346324 cites W2111088142 @default.
- W2741346324 cites W2115923216 @default.
- W2741346324 cites W2119084059 @default.
- W2741346324 cites W2124821411 @default.
- W2741346324 cites W2132561989 @default.
- W2741346324 cites W2133879162 @default.
- W2741346324 cites W2134798732 @default.
- W2741346324 cites W2140342767 @default.
- W2741346324 cites W2165525914 @default.
- W2741346324 cites W2167991458 @default.
- W2741346324 cites W2171649986 @default.
- W2741346324 cites W2311460578 @default.
- W2741346324 cites W2344934244 @default.
- W2741346324 cites W2347060853 @default.
- W2741346324 cites W2412016700 @default.
- W2741346324 cites W2517455217 @default.
- W2741346324 cites W2527196615 @default.
- W2741346324 cites W2533576461 @default.
- W2741346324 cites W2558469082 @default.
- W2741346324 cites W2588047006 @default.
- W2741346324 cites W2623904994 @default.
- W2741346324 cites W3134302526 @default.
- W2741346324 doi "https://doi.org/10.1016/j.hrthm.2017.07.032" @default.
- W2741346324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5712256" @default.
- W2741346324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28765088" @default.
- W2741346324 hasPublicationYear "2017" @default.
- W2741346324 type Work @default.
- W2741346324 sameAs 2741346324 @default.
- W2741346324 citedByCount "27" @default.
- W2741346324 countsByYear W27413463242018 @default.
- W2741346324 countsByYear W27413463242019 @default.
- W2741346324 countsByYear W27413463242020 @default.
- W2741346324 countsByYear W27413463242021 @default.
- W2741346324 countsByYear W27413463242022 @default.
- W2741346324 countsByYear W27413463242023 @default.
- W2741346324 crossrefType "journal-article" @default.
- W2741346324 hasAuthorship W2741346324A5048118890 @default.
- W2741346324 hasAuthorship W2741346324A5084060067 @default.
- W2741346324 hasBestOaLocation W27413463242 @default.