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- W2741387966 abstract "Amyloidogenic peptides play an important role in neurodegeneration. Recently, thereare reports on the nuclear localization of amyloids and proposed to have implicationsto DNA damage and neuronal apoptosis. The mechanism of amyloidogenic peptidesinduced neuronal cell death is still not clear. Our main questions are, (i) mapping ofamyloidogenic peptides induced genotoxicity; (ii) A(1-42) induced genomicinstability in aged rabbits and (iii) to study anti-amyloidogenic properties ofindigenous plants. To achieve these objectives we have employed agarose gel, Tm,EtBr binding, DNase I sensitivity assay, CD, MRI and TEM techniques. The resultsare summarized as follows: (i) A fragments (1-11, 1-28, 1-40 and 1-42) nick scDNAand causes the open circular and linear forms. The Mg2+ ion enhanced the nickingactivity of A fragments (1-11, 1-28, 1-40 and 1-42). The modification of histidine ofA(1-11) abolished the DNA nicking activity. The DNA instability by studying Tmand EtBr binding revealed that DNA became unstable in presence of differentfragments of A. (ii) The aged (4 yr) New Zealand rabbits were intracisternallyinjected with A(1-42) and DNA analyzed from aged rabbits for stability showed thatDNA is damaged in FC and H; where as in M, DNA is in condensed state. The DNAconformation study evidenced the presence of C, and - type DNA conformationsin FC, H and M of A(1-42) injected (25 days) rabbit brain regions respectively. MRIstudies showed no significant changes in brain structures between control and A(1-42) injected aged rabbit brain regions. MRI scanning before and after 45 days of Ainjection found significant reduction in the thickness of hippocampus, temporal lope,frontal lobe, and midbrain and an increase in lateral ventricle volume. Additionally,the aqueous leaf extracts of C. crista and C .asiatica could not prevent the DNAnicking activity of A(1-42). The CG and VG induced modified conformations inA(1-11), A(1-28) and A(25-35). The aqueous extracts of C. crista and C. asiaticashowed anti-oxidant and anti-inflammatory activities. The C. crista showed antiamyloidogenicproperties." @default.
- W2741387966 created "2017-08-08" @default.
- W2741387966 creator A5068512572 @default.
- W2741387966 date "2010-01-01" @default.
- W2741387966 modified "2023-09-27" @default.
- W2741387966 title "Mapping of amyloidogenic peptidesinduced genotoxicity in relevance to neuronal cell death" @default.
- W2741387966 hasPublicationYear "2010" @default.
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