Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741393094> ?p ?o ?g. }
- W2741393094 abstract "Abstract Platelet activation is a major (patho‐) physiological mechanism that underlies ischemia/reperfusion (I/R) injury. In this study, we explored the molecular signals for platelet hyperactivity and investigated the beneficial effects of melatonin on platelet reactivity in response to I/R injury. After reperfusion, peroxisome proliferator‐activated receptor γ ( PPAR γ) was progressively downregulated in patients with acute myocardial infarction undergoing coronary artery bypass grafting ( CABG ) surgery and in mice with I/R injury model. Loss of PPAR γ was closely associated with FUN 14 domain containing 1 ( FUNDC 1) dephosphorylation and mitophagy activation, leading to increased mitochondrial electron transport chain complex ( ETC. ) activity, enhanced mitochondrial respiratory function, and elevated ATP production. The improved mitochondrial function strongly contributed to platelet aggregation, spreading, expression of P‐selectin, and final formation of micro‐thromboses, eventually resulting in myocardial dysfunction and microvascular structural destruction. However, melatonin powerfully suppressed platelet activation via restoration of the PPAR γ content in platelets, which subsequently blocked FUNDC 1‐required mitophagy, mitochondrial energy production, platelet hyperactivity, and cardiac I/R injury. In contrast, genetic ablation of PPAR γ in platelet abolished the beneficial effects of melatonin on mitophagy, mitochondrial ATP supply, and platelet activation. Our results lay the foundation for the molecular mechanism of platelet activation in response to I/R injury and highlight that the manipulation of the PPAR γ/ FUNDC 1/mitophagy pathway by melatonin could be a novel strategy for cardioprotection in the setting of cardiac I/R injury." @default.
- W2741393094 created "2017-08-08" @default.
- W2741393094 creator A5007706452 @default.
- W2741393094 creator A5013015302 @default.
- W2741393094 creator A5015980953 @default.
- W2741393094 creator A5019266355 @default.
- W2741393094 creator A5026641678 @default.
- W2741393094 creator A5039732609 @default.
- W2741393094 creator A5045213014 @default.
- W2741393094 creator A5051863134 @default.
- W2741393094 creator A5068303631 @default.
- W2741393094 creator A5075736599 @default.
- W2741393094 creator A5084136821 @default.
- W2741393094 date "2017-08-21" @default.
- W2741393094 modified "2023-10-16" @default.
- W2741393094 title "Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via <scp>PPAR</scp>γ/<scp>FUNDC</scp>1/mitophagy pathways" @default.
- W2741393094 cites W1791964824 @default.
- W2741393094 cites W1809361764 @default.
- W2741393094 cites W1821702566 @default.
- W2741393094 cites W1877005293 @default.
- W2741393094 cites W1970900504 @default.
- W2741393094 cites W2015920145 @default.
- W2741393094 cites W2023688704 @default.
- W2741393094 cites W2032034964 @default.
- W2741393094 cites W2038859429 @default.
- W2741393094 cites W2047458465 @default.
- W2741393094 cites W2047490672 @default.
- W2741393094 cites W2052586702 @default.
- W2741393094 cites W2062229082 @default.
- W2741393094 cites W2068805278 @default.
- W2741393094 cites W2068870042 @default.
- W2741393094 cites W2076378891 @default.
- W2741393094 cites W2082920565 @default.
- W2741393094 cites W2088315278 @default.
- W2741393094 cites W2093754419 @default.
- W2741393094 cites W2100315973 @default.
- W2741393094 cites W2124895037 @default.
- W2741393094 cites W2152199199 @default.
- W2741393094 cites W2166847826 @default.
- W2741393094 cites W2173193594 @default.
- W2741393094 cites W2178198859 @default.
- W2741393094 cites W2178493867 @default.
- W2741393094 cites W2181196867 @default.
- W2741393094 cites W2253041227 @default.
- W2741393094 cites W2256669978 @default.
- W2741393094 cites W2263904935 @default.
- W2741393094 cites W2297782609 @default.
- W2741393094 cites W2332664660 @default.
- W2741393094 cites W2343798504 @default.
- W2741393094 cites W2346073921 @default.
- W2741393094 cites W2412299019 @default.
- W2741393094 cites W2413899881 @default.
- W2741393094 cites W2434079992 @default.
- W2741393094 cites W2481987364 @default.
- W2741393094 cites W2483878508 @default.
- W2741393094 cites W2495839056 @default.
- W2741393094 cites W2527692420 @default.
- W2741393094 cites W2529225907 @default.
- W2741393094 cites W2531290405 @default.
- W2741393094 cites W2533224625 @default.
- W2741393094 cites W2545426107 @default.
- W2741393094 cites W2547486604 @default.
- W2741393094 cites W2553045487 @default.
- W2741393094 cites W2556584415 @default.
- W2741393094 cites W2563178690 @default.
- W2741393094 cites W2574592954 @default.
- W2741393094 cites W2591395115 @default.
- W2741393094 cites W2596407801 @default.
- W2741393094 cites W2597782214 @default.
- W2741393094 cites W2605501320 @default.
- W2741393094 cites W2606009121 @default.
- W2741393094 cites W2610939032 @default.
- W2741393094 cites W2619239628 @default.
- W2741393094 cites W2619679778 @default.
- W2741393094 cites W9913274 @default.
- W2741393094 doi "https://doi.org/10.1111/jpi.12438" @default.
- W2741393094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28749565" @default.
- W2741393094 hasPublicationYear "2017" @default.
- W2741393094 type Work @default.
- W2741393094 sameAs 2741393094 @default.
- W2741393094 citedByCount "192" @default.
- W2741393094 countsByYear W27413930942017 @default.
- W2741393094 countsByYear W27413930942018 @default.
- W2741393094 countsByYear W27413930942019 @default.
- W2741393094 countsByYear W27413930942020 @default.
- W2741393094 countsByYear W27413930942021 @default.
- W2741393094 countsByYear W27413930942022 @default.
- W2741393094 countsByYear W27413930942023 @default.
- W2741393094 crossrefType "journal-article" @default.
- W2741393094 hasAuthorship W2741393094A5007706452 @default.
- W2741393094 hasAuthorship W2741393094A5013015302 @default.
- W2741393094 hasAuthorship W2741393094A5015980953 @default.
- W2741393094 hasAuthorship W2741393094A5019266355 @default.
- W2741393094 hasAuthorship W2741393094A5026641678 @default.
- W2741393094 hasAuthorship W2741393094A5039732609 @default.
- W2741393094 hasAuthorship W2741393094A5045213014 @default.
- W2741393094 hasAuthorship W2741393094A5051863134 @default.
- W2741393094 hasAuthorship W2741393094A5068303631 @default.
- W2741393094 hasAuthorship W2741393094A5075736599 @default.
- W2741393094 hasAuthorship W2741393094A5084136821 @default.