FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741418323> ?p ?o ?g. }

• W2741418323 endingPage "1819" @default.
• W2741418323 startingPage "1811" @default.
• W2741418323 abstract "Sex differences have been increasingly highlighted in complex regional pain syndrome (CRPS) in clinical practice. In CRPS type I (CRPS-I), although inflammation and oxidative stress have been implicated in its pathogenesis, whether pain behavior and the underlying mechanism are sex-specific is unclear. In the present study, we sought to explore whether sex differences have an impact on inflammation, oxidative stress, and pain sensitivity in CRPS-I.Chronic post-ischemia pain (CPIP) was established in both male and female mice as an animal model of CRPS-I. Edema and mechanical allodynia of bilateral hind paws were assessed after reperfusion. Blood samples were analyzed for serum levels of oxidative stress markers and inflammatory cytokines.Both male and female mice developed edema. Male mice developed CPIP at day 3 after reperfusion; female mice developed CPIP at day 2 after reperfusion. Female mice displayed significantly earlier and higher mechanical allodynia in the ischemic hind paw, which was associated with higher serum levels of IL-2, TNF-α, isoprostanes, 8 OhdG, and malondialdehyde at day 2 after reperfusion. Moreover, female mice showed significantly lower SOD and IL-4 compared to male mice at day 2 after reperfusion.Our results indicate that sex differences in inflammatory and oxidative stress states may play a central role in the sex-specific nociceptive hypersensitivity in CRPS-I, and offer a new insight into pharmacology treatments to improve pain management with CRPS." @default.
• W2741418323 created "2017-08-08" @default.
• W2741418323 creator A5001567597 @default.
• W2741418323 creator A5005426960 @default.
• W2741418323 creator A5007866518 @default.
• W2741418323 creator A5009358113 @default.
• W2741418323 creator A5021993363 @default.
• W2741418323 creator A5053170159 @default.
• W2741418323 creator A5059553591 @default.
• W2741418323 creator A5078370650 @default.
• W2741418323 creator A5087980819 @default.
• W2741418323 date "2017-07-01" @default.
• W2741418323 modified "2023-10-14" @default.
• W2741418323 title "Sex differences in complex regional pain syndrome type I (CRPS-I) in mice" @default.
• W2741418323 cites W1493010294 @default.
• W2741418323 cites W1505254784 @default.
• W2741418323 cites W1559912603 @default.
• W2741418323 cites W1559966832 @default.
• W2741418323 cites W1876272959 @default.
• W2741418323 cites W1941997998 @default.
• W2741418323 cites W1958316722 @default.
• W2741418323 cites W1960722250 @default.
• W2741418323 cites W1964713447 @default.
• W2741418323 cites W1976266513 @default.
• W2741418323 cites W1989153207 @default.
• W2741418323 cites W2027642651 @default.
• W2741418323 cites W2036212062 @default.
• W2741418323 cites W2040025789 @default.
• W2741418323 cites W2044023080 @default.
• W2741418323 cites W2051534775 @default.
• W2741418323 cites W2066245150 @default.
• W2741418323 cites W2074113950 @default.
• W2741418323 cites W2080943118 @default.
• W2741418323 cites W2092595668 @default.
• W2741418323 cites W2093661868 @default.
• W2741418323 cites W2093703392 @default.
• W2741418323 cites W2094172517 @default.
• W2741418323 cites W2130405422 @default.
• W2741418323 cites W2142295577 @default.
• W2741418323 cites W2157837017 @default.
• W2741418323 cites W2159203244 @default.
• W2741418323 cites W2161161114 @default.
• W2741418323 cites W2164791359 @default.
• W2741418323 cites W2169553008 @default.
• W2741418323 cites W2191527223 @default.
• W2741418323 cites W2196308323 @default.
• W2741418323 cites W2275514968 @default.
• W2741418323 cites W2414262666 @default.
• W2741418323 cites W2520457704 @default.
• W2741418323 cites W2529277525 @default.
• W2741418323 cites W2558638935 @default.
• W2741418323 cites W2564223953 @default.
• W2741418323 cites W2567182377 @default.
• W2741418323 cites W2588883201 @default.
• W2741418323 cites W2594459623 @default.
• W2741418323 cites W981694460 @default.
• W2741418323 doi "https://doi.org/10.2147/jpr.s139365" @default.
• W2741418323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5548282" @default.
• W2741418323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28831269" @default.
• W2741418323 hasPublicationYear "2017" @default.
• W2741418323 type Work @default.
• W2741418323 sameAs 2741418323 @default.
• W2741418323 citedByCount "20" @default.
• W2741418323 countsByYear W27414183232018 @default.
• W2741418323 countsByYear W27414183232019 @default.
• W2741418323 countsByYear W27414183232020 @default.
• W2741418323 countsByYear W27414183232021 @default.
• W2741418323 countsByYear W27414183232022 @default.
• W2741418323 countsByYear W27414183232023 @default.
• W2741418323 crossrefType "journal-article" @default.
• W2741418323 hasAuthorship W2741418323A5001567597 @default.
• W2741418323 hasAuthorship W2741418323A5005426960 @default.
• W2741418323 hasAuthorship W2741418323A5007866518 @default.
• W2741418323 hasAuthorship W2741418323A5009358113 @default.
• W2741418323 hasAuthorship W2741418323A5021993363 @default.
• W2741418323 hasAuthorship W2741418323A5053170159 @default.
• W2741418323 hasAuthorship W2741418323A5059553591 @default.
• W2741418323 hasAuthorship W2741418323A5078370650 @default.
• W2741418323 hasAuthorship W2741418323A5087980819 @default.
• W2741418323 hasBestOaLocation W27414183231 @default.
• W2741418323 hasConcept C126322002 @default.
• W2741418323 hasConcept C134018914 @default.
• W2741418323 hasConcept C15490471 @default.
• W2741418323 hasConcept C170493617 @default.
• W2741418323 hasConcept C1862650 @default.
• W2741418323 hasConcept C2776151105 @default.
• W2741418323 hasConcept C2776914184 @default.
• W2741418323 hasConcept C2777883359 @default.
• W2741418323 hasConcept C2778401633 @default.
• W2741418323 hasConcept C2779245659 @default.
• W2741418323 hasConcept C2780226346 @default.
• W2741418323 hasConcept C2780886150 @default.
• W2741418323 hasConcept C2780942790 @default.
• W2741418323 hasConcept C2781118164 @default.
• W2741418323 hasConcept C42219234 @default.
• W2741418323 hasConcept C71924100 @default.
• W2741418323 hasConceptScore W2741418323C126322002 @default.
• W2741418323 hasConceptScore W2741418323C134018914 @default.

• next