Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741459994> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2741459994 endingPage "71" @default.
- W2741459994 startingPage "63" @default.
- W2741459994 abstract "P-glycoprotein (Pgp) is a drug efflux transporter and is the encoded product of the human multidrug resistance gene ABCB1 (MDR1). Pgp is expressed in the blood-brain barrier (BBB) and blood- cerebrospinal fluid (CSF) barrier, and reduces the brain penetration of antiepileptic drugs (AEDs). Functional polymorphism or overexpression of Pgp in the BBB of patients with epilepsy may play a role in pharmacoresistance. The aim of this study was to investigate the possible association of ABCB1 gene polymorphisms C1236T in exon 12, G2677T in exon 21, and C3435T in exon 26 with the development of resistance to antiepileptic therapy. All patients enrolled in the study had an established diagnosis of partial complex epilepsy with or without secondary generalisation and have been suffering from it for more than two years. Patients were devided into two groups. The first group comprised 57 patients refractory to the current therapy, while group 2 consisted of 48 patients with well-controled seizures. Results of our study showed statistically significant difference in the allele and genotype frequency of ABCB1 G2677T between resistant and nonresistant patients. Haplotype G2677/C3435/C1236 was overrepresented among resistant patients. According to our results, ABCB1 variants C1236T, G2677T and C3435T might be associated with therapeutic response to AED in patients with partial epilepsy with or without secondary generalization and represent a possible predictive factor for pharmacoresistance." @default.
- W2741459994 created "2017-08-08" @default.
- W2741459994 creator A5022124437 @default.
- W2741459994 creator A5024301122 @default.
- W2741459994 creator A5027162696 @default.
- W2741459994 creator A5031579075 @default.
- W2741459994 creator A5037626813 @default.
- W2741459994 creator A5075534252 @default.
- W2741459994 creator A5080310344 @default.
- W2741459994 creator A5084285855 @default.
- W2741459994 date "2011-01-01" @default.
- W2741459994 modified "2023-09-26" @default.
- W2741459994 title "ABCB1 gene variants as predictors of multidrug- resistant epilepsy in Croatian population" @default.
- W2741459994 hasPublicationYear "2011" @default.
- W2741459994 type Work @default.
- W2741459994 sameAs 2741459994 @default.
- W2741459994 citedByCount "0" @default.
- W2741459994 crossrefType "journal-article" @default.
- W2741459994 hasAuthorship W2741459994A5022124437 @default.
- W2741459994 hasAuthorship W2741459994A5024301122 @default.
- W2741459994 hasAuthorship W2741459994A5027162696 @default.
- W2741459994 hasAuthorship W2741459994A5031579075 @default.
- W2741459994 hasAuthorship W2741459994A5037626813 @default.
- W2741459994 hasAuthorship W2741459994A5075534252 @default.
- W2741459994 hasAuthorship W2741459994A5080310344 @default.
- W2741459994 hasAuthorship W2741459994A5084285855 @default.
- W2741459994 hasConcept C104317684 @default.
- W2741459994 hasConcept C114851261 @default.
- W2741459994 hasConcept C118552586 @default.
- W2741459994 hasConcept C126322002 @default.
- W2741459994 hasConcept C133936738 @default.
- W2741459994 hasConcept C135763542 @default.
- W2741459994 hasConcept C170493617 @default.
- W2741459994 hasConcept C180754005 @default.
- W2741459994 hasConcept C197754878 @default.
- W2741459994 hasConcept C200082930 @default.
- W2741459994 hasConcept C2777295592 @default.
- W2741459994 hasConcept C2778173252 @default.
- W2741459994 hasConcept C2778186239 @default.
- W2741459994 hasConcept C2778707650 @default.
- W2741459994 hasConcept C2908647359 @default.
- W2741459994 hasConcept C36823959 @default.
- W2741459994 hasConcept C54355233 @default.
- W2741459994 hasConcept C71924100 @default.
- W2741459994 hasConcept C86803240 @default.
- W2741459994 hasConcept C98274493 @default.
- W2741459994 hasConcept C99454951 @default.
- W2741459994 hasConceptScore W2741459994C104317684 @default.
- W2741459994 hasConceptScore W2741459994C114851261 @default.
- W2741459994 hasConceptScore W2741459994C118552586 @default.
- W2741459994 hasConceptScore W2741459994C126322002 @default.
- W2741459994 hasConceptScore W2741459994C133936738 @default.
- W2741459994 hasConceptScore W2741459994C135763542 @default.
- W2741459994 hasConceptScore W2741459994C170493617 @default.
- W2741459994 hasConceptScore W2741459994C180754005 @default.
- W2741459994 hasConceptScore W2741459994C197754878 @default.
- W2741459994 hasConceptScore W2741459994C200082930 @default.
- W2741459994 hasConceptScore W2741459994C2777295592 @default.
- W2741459994 hasConceptScore W2741459994C2778173252 @default.
- W2741459994 hasConceptScore W2741459994C2778186239 @default.
- W2741459994 hasConceptScore W2741459994C2778707650 @default.
- W2741459994 hasConceptScore W2741459994C2908647359 @default.
- W2741459994 hasConceptScore W2741459994C36823959 @default.
- W2741459994 hasConceptScore W2741459994C54355233 @default.
- W2741459994 hasConceptScore W2741459994C71924100 @default.
- W2741459994 hasConceptScore W2741459994C86803240 @default.
- W2741459994 hasConceptScore W2741459994C98274493 @default.
- W2741459994 hasConceptScore W2741459994C99454951 @default.
- W2741459994 hasIssue "2" @default.
- W2741459994 hasLocation W27414599941 @default.
- W2741459994 hasOpenAccess W2741459994 @default.
- W2741459994 hasPrimaryLocation W27414599941 @default.
- W2741459994 hasRelatedWork W1976651748 @default.
- W2741459994 hasRelatedWork W1984882006 @default.
- W2741459994 hasRelatedWork W1998742400 @default.
- W2741459994 hasRelatedWork W2000514484 @default.
- W2741459994 hasRelatedWork W2006338832 @default.
- W2741459994 hasRelatedWork W2020447663 @default.
- W2741459994 hasRelatedWork W2030449842 @default.
- W2741459994 hasRelatedWork W2064263196 @default.
- W2741459994 hasRelatedWork W2081281742 @default.
- W2741459994 hasRelatedWork W2089164698 @default.
- W2741459994 hasRelatedWork W2095832157 @default.
- W2741459994 hasRelatedWork W2110526135 @default.
- W2741459994 hasRelatedWork W2135116638 @default.
- W2741459994 hasRelatedWork W2316600851 @default.
- W2741459994 hasRelatedWork W2374970074 @default.
- W2741459994 hasRelatedWork W2774775365 @default.
- W2741459994 hasRelatedWork W2777920139 @default.
- W2741459994 hasRelatedWork W2794578711 @default.
- W2741459994 hasRelatedWork W2794672308 @default.
- W2741459994 hasRelatedWork W2794944526 @default.
- W2741459994 hasVolume "60" @default.
- W2741459994 isParatext "false" @default.
- W2741459994 isRetracted "false" @default.
- W2741459994 magId "2741459994" @default.
- W2741459994 workType "article" @default.