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- W2741465900 abstract "Background: Cathepsin Sisamemberofthefamily of cysteine lysosomal proteases. Thedistribution ofcathepsinSisrestricted tocells fromthemononuclear lineage bothinthebrain andintheperiphery. Also, its protease activity isuniquely stable atneutral pH. Materials andMethods: We compared theexpression ofcathepsin S,B,andLmRNAsinvarious undifferentiatedanddifferentiated cells ofmononuclear origin, and examined themodulation ofthese mRNAsbyinflammatorymediators (lipopolysaccharide andvarious cytokines). Inaddition, theeffect ofthese agents oncathepsinS protein levels andprotease activity wasalso determined. Lastly, theability ofcathepsin Stoprocess basement membrane components suchasheparan sulfate proteoglycans invitro andinvivowasassessed. Results: Cathepsin S,B,andLmRNAsareexpressed in maturemacrophages andmicroglial cells andnotinundifferentiated monocytes. Activators ofmacrophages negatively regulate all three transcripts. Consistent with this, treatment withthese agents leads toadecrease in intracellular cathepsin Sprotein levels andactivity. However, thesametreatments result instimulation ofsecreted cathepsin Sactivity. Cathepsin S iscapable of degrading heparan sulfate proteoglycans invitro. Also, whenexpressed inendothelial cells, cathepsin Sautocrinely attenuates thebasic fibroblast growthfactor (bFGF)-mediated binding ofFGFreceptor containing cells toendothelial cells, byacting onbasement membrane proteoglycans. Conclusions: Takentogether, these dataimply that cathepsin Sisaregulatable cysteine protease that plays a role inthedegradation ofextracellular proteins, whose secretion frommacrophages andmicroglia isincreased bysignals that lead toactivation ofthese cells, andmay beimportant inregulating extracellular matrix interactions." @default.
- W2741465900 created "2017-08-08" @default.
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- W2741465900 date "1999-01-01" @default.
- W2741465900 modified "2023-09-24" @default.
- W2741465900 title "InflammatoryMediatorsRegulateCathepsinSin MacrophagesandMicroglia: A Rolein Attenuating HeparanSulfateInteractions" @default.
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