FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741506472> ?p ?o ?g. }

• W2741506472 endingPage "579" @default.
• W2741506472 startingPage "571" @default.
• W2741506472 abstract "Abstract: Purpose: Certain physicochemical characteristics of Candesartan Cilexetil (CC) lead to incomplete oral absorption and poor clinical efficacy. This study assessed the prospect of the use of drug-embedded nanospheres to augment the oral bioavailability of CC. Methods: Baseline studies were conducted to measure the solubility of CC in the polymer. Drug encapsulated poly(lactic acid-co-glycolic acid) nanospheres were prepared by emulsion solvent evaporation method. Five different formulations (C1-C5) were prepared for the varying amount of CC (30-50 mg). Evaluation was carried out for nanospheres characters, drug dissolution and release kinetics. Pharmacokinetics parameters were evaluated in rat model. Results: Solubility of drug in polymer was ~20 mg/100 mg of poly(lactic acid-co-glycolic acid). Values of particle size (200-400 nm), zeta potential (~-25 to -27 mV) and polydispersity index (0.17 to 0.21) were optimal for oral absorption. Morphological studies suggest that the prepared nanospheres were spherical in shape with no aggregation. The nanospheres exhibited biphasic release of CC with an initial burst effect (~50% in 4 h), while it was low and incomplete (~54% in 14 h) with pure drug. Furthermore, drug release from nanospheres appeared to indicate a Korsmeyer–Peppas model (r2=0.981), and diffusion of the drug molecules was by anomalous transport (n=0.74). Greater and rapid absorption of CC was observed from the nanospheres with significantly higher Cmax (599.92 ± 139.36 ng/ml; P<0.0005) and AUC0-∞ (~3 folds; P<0.0001) relative to the pure drug (control). Conclusion: These results suggested that CC loaded nanospheres seems to be a suitable alternative to improve the oral bioavailability and could be further assessed for clinical use. Key words: Nanospheres, Release, Polymer, Evaluation, in vivo, Bioavailability." @default.
• W2741506472 created "2017-08-08" @default.
• W2741506472 creator A5001934184 @default.
• W2741506472 creator A5014070053 @default.
• W2741506472 creator A5059202448 @default.
• W2741506472 creator A5079955860 @default.
• W2741506472 date "2017-09-15" @default.
• W2741506472 modified "2023-10-17" @default.
• W2741506472 title "Poly(lactic acid-co-glycolic acid) Nanospheres Improved the Oral Delivery of Candesartan Cilexetil" @default.
• W2741506472 cites W126730606 @default.
• W2741506472 cites W161660362 @default.
• W2741506472 cites W1969477622 @default.
• W2741506472 cites W2038795968 @default.
• W2741506472 cites W2042973822 @default.
• W2741506472 cites W2051624682 @default.
• W2741506472 cites W2054485411 @default.
• W2741506472 cites W2055037481 @default.
• W2741506472 cites W2071423096 @default.
• W2741506472 cites W2074070212 @default.
• W2741506472 cites W207750005 @default.
• W2741506472 cites W2087032263 @default.
• W2741506472 cites W2095316629 @default.
• W2741506472 cites W2144175913 @default.
• W2741506472 cites W2263926477 @default.
• W2741506472 cites W2290466312 @default.
• W2741506472 cites W2292632202 @default.
• W2741506472 cites W2326676866 @default.
• W2741506472 doi "https://doi.org/10.5530/ijper.51.4.86" @default.
• W2741506472 hasPublicationYear "2017" @default.
• W2741506472 type Work @default.
• W2741506472 sameAs 2741506472 @default.
• W2741506472 citedByCount "14" @default.
• W2741506472 countsByYear W27415064722019 @default.
• W2741506472 countsByYear W27415064722021 @default.
• W2741506472 countsByYear W27415064722022 @default.
• W2741506472 countsByYear W27415064722023 @default.
• W2741506472 crossrefType "journal-article" @default.
• W2741506472 hasAuthorship W2741506472A5001934184 @default.
• W2741506472 hasAuthorship W2741506472A5014070053 @default.
• W2741506472 hasAuthorship W2741506472A5059202448 @default.
• W2741506472 hasAuthorship W2741506472A5079955860 @default.
• W2741506472 hasBestOaLocation W27415064721 @default.
• W2741506472 hasConcept C112705442 @default.
• W2741506472 hasConcept C11432220 @default.
• W2741506472 hasConcept C125287762 @default.
• W2741506472 hasConcept C13965031 @default.
• W2741506472 hasConcept C147789679 @default.
• W2741506472 hasConcept C155574463 @default.
• W2741506472 hasConcept C155672457 @default.
• W2741506472 hasConcept C159985019 @default.
• W2741506472 hasConcept C170493617 @default.
• W2741506472 hasConcept C171250308 @default.
• W2741506472 hasConcept C178790620 @default.
• W2741506472 hasConcept C181389837 @default.
• W2741506472 hasConcept C185592680 @default.
• W2741506472 hasConcept C187530423 @default.
• W2741506472 hasConcept C192562407 @default.
• W2741506472 hasConcept C202751555 @default.
• W2741506472 hasConcept C22979827 @default.
• W2741506472 hasConcept C2775920511 @default.
• W2741506472 hasConcept C2780036600 @default.
• W2741506472 hasConcept C2780165375 @default.
• W2741506472 hasConcept C2780472526 @default.
• W2741506472 hasConcept C2908929049 @default.
• W2741506472 hasConcept C43617362 @default.
• W2741506472 hasConcept C523546767 @default.
• W2741506472 hasConcept C54355233 @default.
• W2741506472 hasConcept C55493867 @default.
• W2741506472 hasConcept C71924100 @default.
• W2741506472 hasConcept C86181022 @default.
• W2741506472 hasConcept C86803240 @default.
• W2741506472 hasConcept C88380143 @default.
• W2741506472 hasConcept C98274493 @default.
• W2741506472 hasConceptScore W2741506472C112705442 @default.
• W2741506472 hasConceptScore W2741506472C11432220 @default.
• W2741506472 hasConceptScore W2741506472C125287762 @default.
• W2741506472 hasConceptScore W2741506472C13965031 @default.
• W2741506472 hasConceptScore W2741506472C147789679 @default.
• W2741506472 hasConceptScore W2741506472C155574463 @default.
• W2741506472 hasConceptScore W2741506472C155672457 @default.
• W2741506472 hasConceptScore W2741506472C159985019 @default.
• W2741506472 hasConceptScore W2741506472C170493617 @default.
• W2741506472 hasConceptScore W2741506472C171250308 @default.
• W2741506472 hasConceptScore W2741506472C178790620 @default.
• W2741506472 hasConceptScore W2741506472C181389837 @default.
• W2741506472 hasConceptScore W2741506472C185592680 @default.
• W2741506472 hasConceptScore W2741506472C187530423 @default.
• W2741506472 hasConceptScore W2741506472C192562407 @default.
• W2741506472 hasConceptScore W2741506472C202751555 @default.
• W2741506472 hasConceptScore W2741506472C22979827 @default.
• W2741506472 hasConceptScore W2741506472C2775920511 @default.
• W2741506472 hasConceptScore W2741506472C2780036600 @default.
• W2741506472 hasConceptScore W2741506472C2780165375 @default.
• W2741506472 hasConceptScore W2741506472C2780472526 @default.
• W2741506472 hasConceptScore W2741506472C2908929049 @default.
• W2741506472 hasConceptScore W2741506472C43617362 @default.
• W2741506472 hasConceptScore W2741506472C523546767 @default.
• W2741506472 hasConceptScore W2741506472C54355233 @default.

• next