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• W2741508056 abstract "The 40,000 neurons of the medulla, the largest visual processing center of the Drosophila brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcription factors specifying different neuronal cell fates. The switch from neuroepithelial cells to neuroblasts is controlled by a complex gene regulatory network and is marked by the expression of the proneural gene l’sc. We discovered that microRNA miR-7 is expressed at the transition between neuroepithelial cells and neuroblasts. We showed that miR-7 promotes neuroepithelial cell-to-neuroblast transition by targeting downstream Notch effectors to limit Notch signaling. miR-7 acts as a buffer to ensure that a precise and stereotypical pattern of transition is maintained, even under conditions of environmental stress, echoing the role that miR-7 plays in the eye imaginal disc. This common mechanism reflects the importance of robust visual system development." @default.
• W2741508056 created "2017-08-08" @default.
• W2741508056 creator A5000236851 @default.
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• W2741508056 date "2017-08-01" @default.
• W2741508056 modified "2023-10-12" @default.
• W2741508056 title "miR-7 Buffers Differentiation in the Developing Drosophila Visual System" @default.
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• W2741508056 doi "https://doi.org/10.1016/j.celrep.2017.07.047" @default.
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