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- W2741520 abstract "Objective: To investigate the importance of the malate-aspartate shuttle (MAS) for cardioprotection by ischemic postconditioning (iPCON). Furthermore, we studied whether postconditioning (iPCON) modulates metabolism of L-glutamate, a key metabolite of the MAS. Methods: Isolated rat hearts were perfused with glucose and subjected to 40 min of global ischemia followed by 120 min reperfusion. iPCON was induced by 6 cycles of 10 sec reperfusion/10 sec ischemia. To inhibit the MAS the amino acid transaminase inhibitor aminooxyacetate (AOA: 0.025 mM) was administered during reperfusion. Hearts were allocated to 4 groups: Control; iPCON; Control + AOA and iPCON + AOA (N=10 in each group) and infarct size and hemodynamic recovery were evaluated. Coronary effluent, microdialysis and myocardial tissue were collected for metabolic measurements. Results : iPCON significantly reduced infarct size when compared to control. Inhibition of the MAS by AOA abolished the infarct reducing effect by postconditioning (Figure 1A). Myocardial release of glutamate was significantly decreased during iPCON (P Conclusion: Activity of the malate-aspartate shuttle is crucial for cardioprotection by iPCON. The mechanisms underlying iPCON includes myocardial glutamate metabolism." @default.
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- W2741520 date "2009-11-03" @default.
- W2741520 modified "2023-10-08" @default.
- W2741520 title "Abstract 3930: Inhibition of the Malate-aspartate Shuttle Abolishes Cardioprotection by Postconditioning in Rat Hearts" @default.
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