FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741569643> ?p ?o ?g. }

• W2741569643 endingPage "132" @default.
• W2741569643 startingPage "132" @default.
• W2741569643 abstract "Bronchiectasis is usually classified as cystic fibrosis (CF) related or CF unrelated (non-CF); the latter is not considered an orphan disease any more, even in developed countries. Irrespective of the underlying etiology, bronchiectasis is the result of interaction between host, pathogens, and environment. Vitamin D is known to be involved in a wide spectrum of significant immunomodulatory effects such as down-regulation of pro-inflammatory cytokines and chemokines. Respiratory epithelial cells constitutively express 1α-hydroxylase leading to the local transformation of the inactive 25(OH)-vitamin D to the active 1,25(OH)2-vitamin D. The latter through its autocrine and paracrine functions up-regulates vitamin D dependent genes with important consequences in the local immunity of lungs. Despite the scarcity of direct evidence on the involvement of vitamin D deficiency states in the development of bronchiectasis in either CF or non-CF patients, it is reasonable to postulate that vitamin D may play some role in the pathogenesis of lung diseases and especially bronchiectasis. The potential contribution of vitamin D deficiency in the process of bronchiectasis is of particular clinical importance, taking into consideration the increasing prevalence of vitamin D deficiency worldwide and the significant morbidity of bronchiectasis. Given the well-established association of vitamin D deficiency with increased inflammation, and the indicative evidence for harmful consequences in lungs, it is intriguing to speculate that the administration of vitamin D supplementation could be a reasonable and cost effective supplementary therapeutic approach for children with non-CF bronchiectasis. Regarding CF patients, maybe in the future as more data become available, we have to re-evaluate our policy on the most appropriate dosage scheme for vitamin D." @default.
• W2741569643 created "2017-08-08" @default.
• W2741569643 creator A5001320822 @default.
• W2741569643 creator A5009410290 @default.
• W2741569643 creator A5048228841 @default.
• W2741569643 creator A5089252360 @default.
• W2741569643 date "2017-01-01" @default.
• W2741569643 modified "2023-09-25" @default.
• W2741569643 title "Role of vitamin D in cystic fibrosis and non-cystic fibrosis bronchiectasis" @default.
• W2741569643 cites W1426335019 @default.
• W2741569643 cites W1507010229 @default.
• W2741569643 cites W1548718770 @default.
• W2741569643 cites W1551028857 @default.
• W2741569643 cites W1645379154 @default.
• W2741569643 cites W1818149717 @default.
• W2741569643 cites W1913078431 @default.
• W2741569643 cites W1963911372 @default.
• W2741569643 cites W1963922664 @default.
• W2741569643 cites W1964562166 @default.
• W2741569643 cites W1964758221 @default.
• W2741569643 cites W1968457230 @default.
• W2741569643 cites W1969631786 @default.
• W2741569643 cites W1973366237 @default.
• W2741569643 cites W1974323440 @default.
• W2741569643 cites W1982399867 @default.
• W2741569643 cites W1985558958 @default.
• W2741569643 cites W1996122273 @default.
• W2741569643 cites W1996321010 @default.
• W2741569643 cites W1996339758 @default.
• W2741569643 cites W1998133979 @default.
• W2741569643 cites W1999646316 @default.
• W2741569643 cites W2000387149 @default.
• W2741569643 cites W2003575314 @default.
• W2741569643 cites W2004250548 @default.
• W2741569643 cites W2004776159 @default.
• W2741569643 cites W2005817924 @default.
• W2741569643 cites W2009108161 @default.
• W2741569643 cites W2011630862 @default.
• W2741569643 cites W2012740575 @default.
• W2741569643 cites W2015039585 @default.
• W2741569643 cites W2015593444 @default.
• W2741569643 cites W2016440249 @default.
• W2741569643 cites W2016568456 @default.
• W2741569643 cites W2016940427 @default.
• W2741569643 cites W2017053649 @default.
• W2741569643 cites W2021501597 @default.
• W2741569643 cites W2024152804 @default.
• W2741569643 cites W2026822440 @default.
• W2741569643 cites W2029081372 @default.
• W2741569643 cites W2029536170 @default.
• W2741569643 cites W2032135309 @default.
• W2741569643 cites W2033607922 @default.
• W2741569643 cites W2035281399 @default.
• W2741569643 cites W2036088433 @default.
• W2741569643 cites W2036586400 @default.
• W2741569643 cites W2036981005 @default.
• W2741569643 cites W2042694782 @default.
• W2741569643 cites W2049914201 @default.
• W2741569643 cites W2062528888 @default.
• W2741569643 cites W2063643788 @default.
• W2741569643 cites W2066270030 @default.
• W2741569643 cites W2068698172 @default.
• W2741569643 cites W2069971522 @default.
• W2741569643 cites W2074736008 @default.
• W2741569643 cites W2075291600 @default.
• W2741569643 cites W2077590888 @default.
• W2741569643 cites W2077677810 @default.
• W2741569643 cites W2078078890 @default.
• W2741569643 cites W2080026927 @default.
• W2741569643 cites W2082188051 @default.
• W2741569643 cites W2082198146 @default.
• W2741569643 cites W2083263009 @default.
• W2741569643 cites W2084126190 @default.
• W2741569643 cites W2084679241 @default.
• W2741569643 cites W2086033441 @default.
• W2741569643 cites W2087440959 @default.
• W2741569643 cites W2088445542 @default.
• W2741569643 cites W2088886718 @default.
• W2741569643 cites W2088966225 @default.
• W2741569643 cites W2089533451 @default.
• W2741569643 cites W2090072597 @default.
• W2741569643 cites W2092450600 @default.
• W2741569643 cites W2093840188 @default.
• W2741569643 cites W2095490841 @default.
• W2741569643 cites W2099126377 @default.
• W2741569643 cites W2099427478 @default.
• W2741569643 cites W2100699853 @default.
• W2741569643 cites W2103010959 @default.
• W2741569643 cites W2103024679 @default.
• W2741569643 cites W2105759002 @default.
• W2741569643 cites W2105916236 @default.
• W2741569643 cites W2106044877 @default.
• W2741569643 cites W2106449126 @default.
• W2741569643 cites W2106459551 @default.
• W2741569643 cites W2110521677 @default.
• W2741569643 cites W2113066640 @default.
• W2741569643 cites W2116151144 @default.
• W2741569643 cites W2120012915 @default.

• next