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- W2741584032 abstract "Aspects ofpH regulation inferret ventricular cellshavebeeninvestigated byusingpH-and sodium-selective microelectrodes inbicarbonate-free Tyrode's solution. Anacidload wasproduced bythetransient application ofNH4Cl(10 or20mmol/l). Acomplete recoveryfromanacid load was still observed after multiple applications ofNH4CI, butamiloride (0.75 or1mmol/l), ablocker of theNa-Hexchanger, increased theacidification andinhibited therecovery.Measurements of intracellular sodium concentration showed a transient decrease during theapplication ofNH4Cl andatransient increase above control values during recoveryfromacidification. Thisincrease was inhibited byamiloride. Intracellular sodium loading (strophanthidin (low calcium-low potassium Tyrode's solution]) didnotinitially causean intracellular pH(p11) change, buttheacidification induced byamiloride underthosecircumstances was larger. Reducing extracellular sodium concentration from155to5orto1.5mmol/1 caused an acidification. Changing extracellular pH (pH.) from6.4to8.4caused an averagelinear change inpH;inthesame direction of0.085 pH; units/pHO units. Themean intracellular buffering capacity measured withtheNH4Clmethodand withtheprotonextrusion mechanismblockedbyamiloride was 36±+15mmolpH-' .-l (mean+SD), approximately halfthatofprevious estimations. Changing themetabolic substrate fromglucose topyruvate inthesuperfusing solution caused anacidification of0.21pHunits. This could bepartially blocked bya.cyano-4-hydroxycinnamate, afinding consistent with apyruvate-H' cotransport andlor apyruvate-OH7 countertransport system being present inventricular cells. The results ofthepresent study showthat ventricular cells caneffectively buffer hydrogen ions andthat an Na-Hexchange system plays a majorroleintheregulation ofpHi.(Circulation Research 1991;68:150-161)" @default.
- W2741584032 created "2017-08-08" @default.
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- W2741584032 date "2013-01-01" @default.
- W2741584032 modified "2023-09-27" @default.
- W2741584032 title "Intracellular pHRegulation inFerret Ventricular Muscle TheRoleofNa-HExchange andtheInfluence of" @default.
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