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- W2741625688 abstract "We have recently isolated an abundant cytosolic pro- tein from human T-cells which specifically binds the immunosuppressive agent, FK-506. The FK-506-bind- ing protein (FKBP) is a member of a novel class of proteins possessing peptidyl-prolyl cis-trans isomerase activity. These proteins are believed to play an impor- tant role in accelerating the rate at which proteins fold into their native conformations. In the present study, we demonstrate that FKBP is not a lymphoid-specific protein, but is widely distributed and phylogenically conserved. FKBP, purified from three sources (a hu- man T-lymphocyte cell line JURKAT, bovine calf thy- mus, and Saccharomyces cerevisiae) exhibit identical molecular weights, immunological cross-reactivities, and a high degree of NH2-terminal amino acid sequence homology. In addition, FKBP from all sources pos- sesses peptidyl-prolyl cis-trans isomerase activity which can be specifically inhibited by FK-506. We conclude that FKBP may serve an important biological function in all eukaryotic cells. The" @default.
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- W2741625688 date "1990-01-01" @default.
- W2741625688 modified "2023-09-23" @default.
- W2741625688 title "The Cytosolic-binding Protein for the Immunosuppressant FK-506 Is Both a Ubiquitous and Highly Conserved Peptidyl-Prolyl" @default.
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