FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741640404> ?p ?o ?g. }

• W2741640404 endingPage "34" @default.
• W2741640404 startingPage "33" @default.
• W2741640404 abstract "Introduction: Clinical studies have shown that adverse events in childhood can lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in humans. Manipulations with laboratory animals, such as maternal deprivation (MD), are a source of stress for the offspring and can be a useful tool for the understanding how these events in the early period of development can lead to behavioral changes in adulthood. Studies about the use of homeopathic ultra-high dilutions as tools to minimize stress are found in the literature, i.e. Zincum metallicum is used for the treatment of neurological and behavioral symptoms, including: weakening of intellectual functions with brain and nervous exhaustion, loss of vitality, slow comprehension, memory disorder, general tremor and constant movements. These alterations can be characterized as stress-related phenomena in different species. &#x0D; Aim: The aim of this study was to evaluate the long-term effects of homeopathic treatment in animals subjected to stress in their early days (maternal deprivation). This study was approved by the Ethics Committee of the University of Santo Amaro (UNISA), according to Process number 11/2014.&#x0D; Materials and Methods: In this study, newborn female rats were subjected to maternal deprivation and treated from the 10th day of lactation (PND10) until weaning (PND21). The animals were divided in 4 groups: 8 treated with Zincum metallicum 30 cH (Zn30cH); 8 treated with Zincum metallicum 6 cH (Zn6cH); 8 treated with 10% hydroalcoholic solution (medicines in blind trials, identified by codes); and 8 animals who had neither taken anything (“blank control”) nor experienced deprivation. The animals were weighed weekly, from weaning until the end of the experiment, and evaluated in the Open Field (OF) and in the Plus Maze (PM) devices to measure mobility, emotionality and anxiety, in 3 moments: in PND21 (childhood), during puberty (PND 40) and adulthood (PND75). Data were analyzed statistically by ANOVA, followed by the Bartlett's Test and Bonferroni's Multiple Comparison Test, being p≤0.05. &#x0D; Results and Discussion: In the OF, it was observed reduction of immobility in Zn6cH group (p≤0.05) at PND21. At PND40, the Zn30cH group showed higher activity than the other groups, with increased rearing and decreased immobility (p≤0.05). Finely, at PND75 (adulthood) no change occurred, and Zincum metallicum treated rats presented similar behavior to the undeprived animals. In the PM, at PND21, the Zn30cH treated deprived group showed decrease in the open arm entry and retention period in the Maze, compared to the control undeprived group (p≤0.05). The time in the closed arm was higher than the undeprived control group and the number of head dips was lower (p≤0.05). The PM observation at 45 and 75 days showed no statistical difference among groups. The deprived animals which took Zn30cH obtained the same gain that the undeprived animals did (p≤0.05). Therefore, the deprived animals that presented anxiety during childhood were in accordance to other studies, showing that maternal deprivation is a stress factor that causes anxiety. However, the time of emotional unbalance was shorter in rats treated with Zincum metallicum. &#x0D; Conclusion: Zincum metallicum 30 cH seems to be a potential medicine to manage troubles in the childhood derived from stress caused by maternal deprivation. However, other studies are already underway with male offspring and neurochemical measurements, for a better parameter of results." @default.
• W2741640404 created "2017-08-08" @default.
• W2741640404 creator A5009595581 @default.
• W2741640404 creator A5033288837 @default.
• W2741640404 creator A5034083695 @default.
• W2741640404 creator A5040617090 @default.
• W2741640404 creator A5052826552 @default.
• W2741640404 creator A5059269851 @default.
• W2741640404 creator A5062738605 @default.
• W2741640404 creator A5071438008 @default.
• W2741640404 date "2021-08-27" @default.
• W2741640404 modified "2023-10-17" @default.
• W2741640404 title "Assessment of the effects of maternal deprivation in offspring treated with ultra-high diluted Zincum metallicum in rats" @default.
• W2741640404 doi "https://doi.org/10.51910/ijhdr.v14i2.781" @default.
• W2741640404 hasPublicationYear "2021" @default.
• W2741640404 type Work @default.
• W2741640404 sameAs 2741640404 @default.
• W2741640404 citedByCount "0" @default.
• W2741640404 crossrefType "journal-article" @default.
• W2741640404 hasAuthorship W2741640404A5009595581 @default.
• W2741640404 hasAuthorship W2741640404A5033288837 @default.
• W2741640404 hasAuthorship W2741640404A5034083695 @default.
• W2741640404 hasAuthorship W2741640404A5040617090 @default.
• W2741640404 hasAuthorship W2741640404A5052826552 @default.
• W2741640404 hasAuthorship W2741640404A5059269851 @default.
• W2741640404 hasAuthorship W2741640404A5062738605 @default.
• W2741640404 hasAuthorship W2741640404A5071438008 @default.
• W2741640404 hasBestOaLocation W27416404041 @default.
• W2741640404 hasConcept C112672928 @default.
• W2741640404 hasConcept C118552586 @default.
• W2741640404 hasConcept C123202247 @default.
• W2741640404 hasConcept C126322002 @default.
• W2741640404 hasConcept C15744967 @default.
• W2741640404 hasConcept C2776659692 @default.
• W2741640404 hasConcept C2779234561 @default.
• W2741640404 hasConcept C2780655333 @default.
• W2741640404 hasConcept C42407357 @default.
• W2741640404 hasConcept C54355233 @default.
• W2741640404 hasConcept C71924100 @default.
• W2741640404 hasConcept C86803240 @default.
• W2741640404 hasConceptScore W2741640404C112672928 @default.
• W2741640404 hasConceptScore W2741640404C118552586 @default.
• W2741640404 hasConceptScore W2741640404C123202247 @default.
• W2741640404 hasConceptScore W2741640404C126322002 @default.
• W2741640404 hasConceptScore W2741640404C15744967 @default.
• W2741640404 hasConceptScore W2741640404C2776659692 @default.
• W2741640404 hasConceptScore W2741640404C2779234561 @default.
• W2741640404 hasConceptScore W2741640404C2780655333 @default.
• W2741640404 hasConceptScore W2741640404C42407357 @default.
• W2741640404 hasConceptScore W2741640404C54355233 @default.
• W2741640404 hasConceptScore W2741640404C71924100 @default.
• W2741640404 hasConceptScore W2741640404C86803240 @default.
• W2741640404 hasIssue "2" @default.
• W2741640404 hasLocation W27416404041 @default.
• W2741640404 hasOpenAccess W2741640404 @default.
• W2741640404 hasPrimaryLocation W27416404041 @default.
• W2741640404 hasRelatedWork W2017628148 @default.
• W2741640404 hasRelatedWork W2034470187 @default.
• W2741640404 hasRelatedWork W2039667989 @default.
• W2741640404 hasRelatedWork W2045910585 @default.
• W2741640404 hasRelatedWork W2057453606 @default.
• W2741640404 hasRelatedWork W2098482731 @default.
• W2741640404 hasRelatedWork W2102849275 @default.
• W2741640404 hasRelatedWork W2120823452 @default.
• W2741640404 hasRelatedWork W2145363909 @default.
• W2741640404 hasRelatedWork W2791218440 @default.
• W2741640404 hasVolume "14" @default.
• W2741640404 isParatext "false" @default.
• W2741640404 isRetracted "false" @default.
• W2741640404 magId "2741640404" @default.
• W2741640404 workType "article" @default.