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- W274166047 abstract "Breast cancer is the most common malignancy in women and significant cause of cancer-related deaths, second only to lung cancer. Amongst different subtypes of breast cancers, triple-negative breast cancer (TNBC) is especially challenging due to fewer treatment options and more aggressive clinical course. Therefore, the development of molecularly targeted therapies for TNBC is crucial. Glycoprotein nonmetastatic B (GPNMB) is overexpressed in many malignancies, including TNBC, and is associated with poor prognosis. The antibody—drug conjugate (ADC) glembatumumab vedotin (CDX-011) selectively target GPNMB, and is being investigated for its efficacy in metastatic breast cancer. This chapter reviews the mechanisms of action, preclinical, and phase I/II results of glembatumumab vedotin, and ongoing studies of its role in the treatment of breast cancer." @default.
- W274166047 created "2016-06-24" @default.
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- W274166047 date "2015-01-01" @default.
- W274166047 modified "2023-09-26" @default.
- W274166047 title "The Antibody-Drug Conjugate Glembatumumab Vedotin (CDX-011) and Its Use in Treatment of Breast Cancer" @default.
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- W274166047 doi "https://doi.org/10.1007/978-3-319-13081-1_13" @default.
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