FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741676161> ?p ?o ?g. }

• W2741676161 abstract "Even though the glycine conjugation pathway was one of the first metabolic pathways to be discovered, this pathway remains very poorly characterized. The bi-substrate kinetic parameters of a recombinant human glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13) were determined using the traditional colorimetric method and a newly developed HPLC-ESI-MS/MS method. Previous studies analyzing the kinetic parameters of GLYAT, indicated a random Bi-Bi and/or ping-pong mechanism. In this study, the hippuric acid concentrations produced by the GLYAT enzyme reaction were analyzed using the allosteric sigmoidal enzyme kinetic module. Analyses of the initial rate (v) against substrate concentration plots, produced a sigmoidal curve (substrate activation) when the benzoyl-CoA concentrations was kept constant, whereas the plot with glycine concentrations kept constant, passed through a maximum (substrate inhibition). Thus, human GLYAT exhibits mechanistic kinetic cooperativity as described by the Ferdinand enzyme mechanism rather than the previously assumed Michaelis-Menten reaction mechanism." @default.
• W2741676161 created "2017-08-08" @default.
• W2741676161 creator A5012590755 @default.
• W2741676161 creator A5022551654 @default.
• W2741676161 creator A5081589040 @default.
• W2741676161 creator A5082183159 @default.
• W2741676161 creator A5087942494 @default.
• W2741676161 date "2017-07-31" @default.
• W2741676161 modified "2023-09-27" @default.
• W2741676161 title "New insights into the catalytic mechanism of human glycine N‐acyltransferase" @default.
• W2741676161 cites W14522412 @default.
• W2741676161 cites W1530639715 @default.
• W2741676161 cites W1981578954 @default.
• W2741676161 cites W1983181572 @default.
• W2741676161 cites W1990842900 @default.
• W2741676161 cites W2006370393 @default.
• W2741676161 cites W2012973022 @default.
• W2741676161 cites W2021474862 @default.
• W2741676161 cites W2026585629 @default.
• W2741676161 cites W2036302548 @default.
• W2741676161 cites W2037622735 @default.
• W2741676161 cites W2045189096 @default.
• W2741676161 cites W2045298158 @default.
• W2741676161 cites W2045629352 @default.
• W2741676161 cites W2063646359 @default.
• W2741676161 cites W2075683547 @default.
• W2741676161 cites W2080023898 @default.
• W2741676161 cites W2107421255 @default.
• W2741676161 cites W2112457344 @default.
• W2741676161 cites W2113873678 @default.
• W2741676161 cites W2118694083 @default.
• W2741676161 cites W2131110533 @default.
• W2741676161 cites W2147842931 @default.
• W2741676161 cites W2188208443 @default.
• W2741676161 cites W2299588678 @default.
• W2741676161 cites W2340661992 @default.
• W2741676161 cites W2418353165 @default.
• W2741676161 cites W4241843748 @default.
• W2741676161 cites W4244606975 @default.
• W2741676161 doi "https://doi.org/10.1002/jbt.21963" @default.
• W2741676161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28759163" @default.
• W2741676161 hasPublicationYear "2017" @default.
• W2741676161 type Work @default.
• W2741676161 sameAs 2741676161 @default.
• W2741676161 citedByCount "6" @default.
• W2741676161 countsByYear W27416761612019 @default.
• W2741676161 countsByYear W27416761612021 @default.
• W2741676161 countsByYear W27416761612022 @default.
• W2741676161 countsByYear W27416761612023 @default.
• W2741676161 crossrefType "journal-article" @default.
• W2741676161 hasAuthorship W2741676161A5012590755 @default.
• W2741676161 hasAuthorship W2741676161A5022551654 @default.
• W2741676161 hasAuthorship W2741676161A5081589040 @default.
• W2741676161 hasAuthorship W2741676161A5082183159 @default.
• W2741676161 hasAuthorship W2741676161A5087942494 @default.
• W2741676161 hasConcept C121332964 @default.
• W2741676161 hasConcept C135889238 @default.
• W2741676161 hasConcept C148898269 @default.
• W2741676161 hasConcept C166014724 @default.
• W2741676161 hasConcept C166342909 @default.
• W2741676161 hasConcept C181199279 @default.
• W2741676161 hasConcept C185592680 @default.
• W2741676161 hasConcept C18903297 @default.
• W2741676161 hasConcept C2777289219 @default.
• W2741676161 hasConcept C2777756961 @default.
• W2741676161 hasConcept C28212737 @default.
• W2741676161 hasConcept C41183919 @default.
• W2741676161 hasConcept C515207424 @default.
• W2741676161 hasConcept C55493867 @default.
• W2741676161 hasConcept C56856141 @default.
• W2741676161 hasConcept C62520636 @default.
• W2741676161 hasConcept C64915919 @default.
• W2741676161 hasConcept C71240020 @default.
• W2741676161 hasConcept C86803240 @default.
• W2741676161 hasConceptScore W2741676161C121332964 @default.
• W2741676161 hasConceptScore W2741676161C135889238 @default.
• W2741676161 hasConceptScore W2741676161C148898269 @default.
• W2741676161 hasConceptScore W2741676161C166014724 @default.
• W2741676161 hasConceptScore W2741676161C166342909 @default.
• W2741676161 hasConceptScore W2741676161C181199279 @default.
• W2741676161 hasConceptScore W2741676161C185592680 @default.
• W2741676161 hasConceptScore W2741676161C18903297 @default.
• W2741676161 hasConceptScore W2741676161C2777289219 @default.
• W2741676161 hasConceptScore W2741676161C2777756961 @default.
• W2741676161 hasConceptScore W2741676161C28212737 @default.
• W2741676161 hasConceptScore W2741676161C41183919 @default.
• W2741676161 hasConceptScore W2741676161C515207424 @default.
• W2741676161 hasConceptScore W2741676161C55493867 @default.
• W2741676161 hasConceptScore W2741676161C56856141 @default.
• W2741676161 hasConceptScore W2741676161C62520636 @default.
• W2741676161 hasConceptScore W2741676161C64915919 @default.
• W2741676161 hasConceptScore W2741676161C71240020 @default.
• W2741676161 hasConceptScore W2741676161C86803240 @default.
• W2741676161 hasFunder F4320320671 @default.
• W2741676161 hasFunder F4320320672 @default.
• W2741676161 hasIssue "11" @default.
• W2741676161 hasLocation W27416761611 @default.
• W2741676161 hasLocation W27416761612 @default.
• W2741676161 hasOpenAccess W2741676161 @default.
• W2741676161 hasPrimaryLocation W27416761611 @default.

• next