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- W2741714178 abstract "The Scandinavian Sarcoma Group (SSG) started its first chemotherapy study in soft tissue sar - coma (STS) in 1981 (SSG I). This study evaluated single agent doxorubicin given adjuvant in a prospective ran- domized trial in patients with high-grade STS. Neither overall survival nor disease-free survival was improved. Combination chemotherapy was hereafter studied in a phase II study (1991-1994) combining ifosfamide and continuous infusion etoposide with growth factor sup- port (SSG X). The response rate in previously untreated patients was high (42%), but complete remissions were few. Analysis made on patients operated after chemo- therapy indicated improved survival in this subgroup. Meta-analyses of adjuvant chemotherapy for localised resectable STS in adults, including the SSG I trial, has indicated improved disease-free survival and a trend towards improved overall survival. Presently, SSG is testing whether such a benefit can be found for adjuvant ifosfamide and doxorubicin treatment given after pri- mary surgery in selected patients with high-grade STS and other well defined unfavourable prognostic factors (SSG XIII). " @default.
- W2741714178 created "2017-08-08" @default.
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- W2741714178 date "2004-01-01" @default.
- W2741714178 modified "2023-09-27" @default.
- W2741714178 title "The Scandinavian Sarcoma Group experience" @default.
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