Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741738894> ?p ?o ?g. }
- W2741738894 abstract "The development of treatments that modulate corneal wound healing to avoid fibrosis during tissue repair is important for the restoration of corneal transparency after an injury. To date, few studies have studied the influence of growth factors (GFs) on human corneal fibroblast (HCF) expression of extracellular matrix (ECM) proteins such as collagen types I and III, proteoglycans such as perlecan, or proteins implicated in cellular migration such as α5β1-integrin and syndecan-4. Using in vitro HCFs, a mechanical wound model was developed to study the influence of the GFs basic fibroblast GF (bFGF), platelet-derived GF (PDGF-BB) and transforming GF-β1 (TGFβ1) on ECM protein production and cellular migration. Our results show that mechanical wounding provokes the autocrine release of bFGF and TGFβ1 at different time points during the wound closure. The HCF response to PDGF-BB was a rapid closure due to fast cellular migration associated with a high focal adhesion replacement and a high expression of collagen and proteoglycans, producing nonfibrotic healing. bFGF stimulated nonfibrotic ECM production and limited the migration process. Finally, TGFβ1 induced expression of the fibrotic markers collagen type III and α5β1 integrin, and it inhibited cellular migration due to the formation of focal adhesions with a low turnover rate. The novel in vitro HCF mechanical wound model can be used to understand the role played by GFs in human corneal repair. The model can also be used to test the effects of different treatments aimed at improving the healing process. Copyright © 2016 John Wiley & Sons, Ltd." @default.
- W2741738894 created "2017-08-08" @default.
- W2741738894 creator A5007177439 @default.
- W2741738894 creator A5010978811 @default.
- W2741738894 creator A5016735120 @default.
- W2741738894 creator A5037407847 @default.
- W2741738894 creator A5052598654 @default.
- W2741738894 creator A5059655739 @default.
- W2741738894 creator A5089714032 @default.
- W2741738894 date "2017-05-12" @default.
- W2741738894 modified "2023-10-18" @default.
- W2741738894 title "Human corneal fibroblast migration and extracellular matrix synthesis during stromal repair: Role played by platelet‐derived growth factor‐BB, basic fibroblast growth factor, and transforming growth factor‐β1" @default.
- W2741738894 cites W1853807720 @default.
- W2741738894 cites W1965368544 @default.
- W2741738894 cites W1965918667 @default.
- W2741738894 cites W1972061655 @default.
- W2741738894 cites W1973064894 @default.
- W2741738894 cites W1974377564 @default.
- W2741738894 cites W1978227510 @default.
- W2741738894 cites W1995061843 @default.
- W2741738894 cites W1996071947 @default.
- W2741738894 cites W2001824373 @default.
- W2741738894 cites W2007894514 @default.
- W2741738894 cites W2008251866 @default.
- W2741738894 cites W2012405750 @default.
- W2741738894 cites W2019550443 @default.
- W2741738894 cites W2021520049 @default.
- W2741738894 cites W2024671298 @default.
- W2741738894 cites W2024966180 @default.
- W2741738894 cites W2028237347 @default.
- W2741738894 cites W2029322193 @default.
- W2741738894 cites W2041221820 @default.
- W2741738894 cites W2042343633 @default.
- W2741738894 cites W2043990687 @default.
- W2741738894 cites W2045191671 @default.
- W2741738894 cites W2051846494 @default.
- W2741738894 cites W2066921686 @default.
- W2741738894 cites W2069563979 @default.
- W2741738894 cites W2079330851 @default.
- W2741738894 cites W2080517676 @default.
- W2741738894 cites W2089798340 @default.
- W2741738894 cites W2091428132 @default.
- W2741738894 cites W2096515643 @default.
- W2741738894 cites W2105809801 @default.
- W2741738894 cites W2120729063 @default.
- W2741738894 cites W2146897705 @default.
- W2741738894 cites W2149667112 @default.
- W2741738894 cites W2150000837 @default.
- W2741738894 cites W2291187754 @default.
- W2741738894 cites W4313777 @default.
- W2741738894 doi "https://doi.org/10.1002/term.2360" @default.
- W2741738894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27860426" @default.
- W2741738894 hasPublicationYear "2017" @default.
- W2741738894 type Work @default.
- W2741738894 sameAs 2741738894 @default.
- W2741738894 citedByCount "13" @default.
- W2741738894 countsByYear W27417388942019 @default.
- W2741738894 countsByYear W27417388942020 @default.
- W2741738894 countsByYear W27417388942021 @default.
- W2741738894 countsByYear W27417388942022 @default.
- W2741738894 crossrefType "journal-article" @default.
- W2741738894 hasAuthorship W2741738894A5007177439 @default.
- W2741738894 hasAuthorship W2741738894A5010978811 @default.
- W2741738894 hasAuthorship W2741738894A5016735120 @default.
- W2741738894 hasAuthorship W2741738894A5037407847 @default.
- W2741738894 hasAuthorship W2741738894A5052598654 @default.
- W2741738894 hasAuthorship W2741738894A5059655739 @default.
- W2741738894 hasAuthorship W2741738894A5089714032 @default.
- W2741738894 hasBestOaLocation W27417388941 @default.
- W2741738894 hasConcept C118131993 @default.
- W2741738894 hasConcept C128240485 @default.
- W2741738894 hasConcept C1491633281 @default.
- W2741738894 hasConcept C151166631 @default.
- W2741738894 hasConcept C170493617 @default.
- W2741738894 hasConcept C180361614 @default.
- W2741738894 hasConcept C185592680 @default.
- W2741738894 hasConcept C189165786 @default.
- W2741738894 hasConcept C195687474 @default.
- W2741738894 hasConcept C202751555 @default.
- W2741738894 hasConcept C203014093 @default.
- W2741738894 hasConcept C2775960820 @default.
- W2741738894 hasConcept C2777587049 @default.
- W2741738894 hasConcept C2780269544 @default.
- W2741738894 hasConcept C2780381497 @default.
- W2741738894 hasConcept C2781294074 @default.
- W2741738894 hasConcept C55493867 @default.
- W2741738894 hasConcept C62478195 @default.
- W2741738894 hasConcept C74373430 @default.
- W2741738894 hasConcept C86803240 @default.
- W2741738894 hasConcept C95444343 @default.
- W2741738894 hasConceptScore W2741738894C118131993 @default.
- W2741738894 hasConceptScore W2741738894C128240485 @default.
- W2741738894 hasConceptScore W2741738894C1491633281 @default.
- W2741738894 hasConceptScore W2741738894C151166631 @default.
- W2741738894 hasConceptScore W2741738894C170493617 @default.
- W2741738894 hasConceptScore W2741738894C180361614 @default.
- W2741738894 hasConceptScore W2741738894C185592680 @default.
- W2741738894 hasConceptScore W2741738894C189165786 @default.
- W2741738894 hasConceptScore W2741738894C195687474 @default.
- W2741738894 hasConceptScore W2741738894C202751555 @default.