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• W2741776504 abstract "Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes in the recipient intestine, which can mask disease-specific attributes of the donor material. Therefore, a simple model of replacing microbiota into a developmentally mature intestinal environment remains highly desirable.Here we report on the development of a sequential, three-course antibiotic conditioning regimen that allows sustained engraftment of intestinal microorganisms following a single oral gavage with human donor microbiota. SourceTracker, a Bayesian, OTU-based algorithm, indicated that 59.3 ± 3.0% of the fecal bacterial communities in treated mice were attributable to the donor source. This overall degree of microbiota engraftment was similar in mice conditioned with antibiotics and germ-free mice. Limited surveys of systemic and mucosal immune sites did not show evidence of immune activation following introduction of human microbiota.The antibiotic treatment protocol described here followed by a single gavage of human microbiota may provide a useful, complimentary HMA model to that established in germ-free facilities. The model has the potential for further in-depth translational investigations of microbiota in a variety of human disease states." @default.
• W2741776504 created "2017-08-08" @default.
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• W2741776504 date "2017-08-01" @default.
• W2741776504 modified "2023-10-14" @default.
• W2741776504 title "Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning" @default.
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• W2741776504 doi "https://doi.org/10.1186/s40168-017-0306-2" @default.
• W2741776504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5537947" @default.
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• W2741776504 hasPublicationYear "2017" @default.
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