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• W2741825985 abstract "A laboratory test has three phases, pre-analytical, analytical and post-analytical. The purpose of this review is to highlight an issue concerning the analytical phase of one of the most widely deployed groups of in vitro diagnostic tests using a common technology - namely immunoassay.Immunoassay entails an inherently high error rate and, therefore, has the potential for inaccurate and misleading results susceptible to misinterpretation and/or diagnostic misapplication by clinicians. An approach based on Bayesian inference (without mathematics or equations) - illustrated by examples - is presented; this may help clinicians in discerning potentially erroneous results even when they appear plausible and not unreasonable.Essentially, false positive results are most likely to occur when the disease prevalence/incidence is low. False negative results become more prominent when the prevalence/incidence of disease increases. When concern is raised, available follow-up laboratory tests should be initiated to establish with confidence the diagnostic reliability or unreliability of such results." @default.
• W2741825985 created "2017-08-08" @default.
• W2741825985 creator A5089983488 @default.
• W2741825985 date "2017-08-01" @default.
• W2741825985 modified "2023-10-05" @default.
• W2741825985 title "When laboratory tests can mislead even when they appear plausible" @default.
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• W2741825985 doi "https://doi.org/10.7861/clinmedicine.17-4-329" @default.
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