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• W2741836010 abstract "The calcium channel plays a key role in controlling many physiological processes in the body. Drugs that block the calcium channel have proven clinically effective for the treatment of a multitude of cardiovascula r disorders. The elucidation of the precise mechanism of action of these drugs involves cloning the calcium channels on which they act. Genetic manipulation of these cloned channels is beginning to reveal the binding sites for the calcium channel blocking drugs and may lead to the development of more specific agents. {Hypertension 1992; 19:19-24) C alcium plays a critical role as an intracellular messenger in the function of many cell types. The maintenance of intracellular and extracellular concentrations of calcium is crucial for the proper function of tissues and organ systems. This is accomplished in part by calcium channels embedded in the plasma membrane of the cells of these tissues. Although not necessarily a direct consequence of abnormal calcium handling, the symptoms of many diseases can now be ameliorated with the use of calcium channel antagonist drugs. Calcium antagonists are used to treat several cardiovascular and cerebrovascular disorders including exertional, PrinzmetaPs variant angina, supraventricular tachyarrhythmias, hypertension, hypertrophic cardiomyopathy, Raynaud's phenomenon, posthemorrhagic cerebral vasospasm,1-3 and migraine headache.3-6 Although only a small number of calcium antagonists are currently available for clinical use, several new drugs are being studied for their potential therapeutic value. The hope is that these drugs will be more selective to particular disease states. To achieve this goal, the mechanism of action of calcium antagonist drugs on the molecular level must be elucidated. This has been made possible by the current techniques of molecular biology. Although the use of molecular genetics in cardiovascular science is a recent development, many strides have been made in a short period of time. Complementary DNAs (cDNAs) encoding putative calcium channels from a number of tissues have been isolated. From the deduced amino acid sequence, the membrane topology can be predicted and compared" @default.
• W2741836010 created "2017-08-08" @default.
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• W2741836010 date "2017-01-01" @default.
• W2741836010 modified "2023-09-27" @default.
• W2741836010 title "Tutorials in Molecular and Cellular Biology Molecular Biology of the Calcium Antagonist Receptor" @default.
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