Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741836698> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2741836698 startingPage "76" @default.
- W2741836698 abstract "Ochratoxin A (OTA) and fumonisin B1 (FB1) are nephrotoxic mycotoxins that contaminate various commodities, and humans are constantly exposed to low levels of these mycotoxins. Aim of this study was to find out whether very low doses of OTA and FB1, given separately or combined, induce oxidative stress in rat liver and kidney, and whether their effect is synergistic. The concentration of malondialdehyde (MDA) (1) and protein carbonyls (PCs) (2) and the activity of catalase (3) and superoxide dismutase (SOD) (4) were measured in the liver and kidney of rats orally treated with OTA (5 ng/kg b.w. and 50 ug/kg b.w.) and FB1 (200 ng/kg b.w. and 50 ug/kg b.w.), or their combinations. The lowest doses in this study correspondents to the estimated daily intake for OTA and FB1 for humans in Europe. The concentration of MDA and PCs was higher in the liver and kidney when 50 ug OTA/kg b.w. was applied (P<0.05). In the kidney, this effect was obtained even with a dose as low as 5 ng OTA/kg b.w.. FB1 did not affect MDA and PC concentrations in the liver, while in the kidney 5 ng FB1/kg b.w. was enough to increase MDA concentration (P<0.05). The combination of the lower doses of OTA+FB1 increased the MDA and PC concentration both in the liver and the kidney, compared to controls and animals treated with respective doses of mycotoxins (P<0.05). The combinations of mycotoxins reduced the catalase activity only in the kidney when compared to controls (P<0.05). In contrast to the increased kidney concentrations of MDA and PCs even with very low doses of OTA and FB1, the activity of catalase and SOD does not change. Combinations of OTA+FB1 affected almost all parameters, which indicate their potential to produce oxidative damage. References: 1. Drury, JA. et al. (1997) Clin Chim Acta 263: 177-185. 2. Mercier, Y. et al. (2004) Meat Sci 66: 467-73. 3. Aebi, H. (1984) Methods Enzymol 105: 121-26. 4. Flohe, L., Otting, F. (1971) Methods Enzymol 105: 93-104." @default.
- W2741836698 created "2017-08-08" @default.
- W2741836698 creator A5040619218 @default.
- W2741836698 creator A5065801147 @default.
- W2741836698 creator A5086813115 @default.
- W2741836698 date "2007-01-01" @default.
- W2741836698 modified "2023-09-27" @default.
- W2741836698 title "The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity" @default.
- W2741836698 hasPublicationYear "2007" @default.
- W2741836698 type Work @default.
- W2741836698 sameAs 2741836698 @default.
- W2741836698 citedByCount "0" @default.
- W2741836698 crossrefType "journal-article" @default.
- W2741836698 hasAuthorship W2741836698A5040619218 @default.
- W2741836698 hasAuthorship W2741836698A5065801147 @default.
- W2741836698 hasAuthorship W2741836698A5086813115 @default.
- W2741836698 hasConcept C126189478 @default.
- W2741836698 hasConcept C126322002 @default.
- W2741836698 hasConcept C178790620 @default.
- W2741836698 hasConcept C185592680 @default.
- W2741836698 hasConcept C2775838275 @default.
- W2741836698 hasConcept C2776008721 @default.
- W2741836698 hasConcept C2776151105 @default.
- W2741836698 hasConcept C2778401633 @default.
- W2741836698 hasConcept C2778431908 @default.
- W2741836698 hasConcept C2778979269 @default.
- W2741836698 hasConcept C2780091579 @default.
- W2741836698 hasConcept C2781429003 @default.
- W2741836698 hasConcept C29730261 @default.
- W2741836698 hasConcept C31903555 @default.
- W2741836698 hasConcept C55493867 @default.
- W2741836698 hasConcept C71924100 @default.
- W2741836698 hasConcept C84699730 @default.
- W2741836698 hasConcept C98274493 @default.
- W2741836698 hasConceptScore W2741836698C126189478 @default.
- W2741836698 hasConceptScore W2741836698C126322002 @default.
- W2741836698 hasConceptScore W2741836698C178790620 @default.
- W2741836698 hasConceptScore W2741836698C185592680 @default.
- W2741836698 hasConceptScore W2741836698C2775838275 @default.
- W2741836698 hasConceptScore W2741836698C2776008721 @default.
- W2741836698 hasConceptScore W2741836698C2776151105 @default.
- W2741836698 hasConceptScore W2741836698C2778401633 @default.
- W2741836698 hasConceptScore W2741836698C2778431908 @default.
- W2741836698 hasConceptScore W2741836698C2778979269 @default.
- W2741836698 hasConceptScore W2741836698C2780091579 @default.
- W2741836698 hasConceptScore W2741836698C2781429003 @default.
- W2741836698 hasConceptScore W2741836698C29730261 @default.
- W2741836698 hasConceptScore W2741836698C31903555 @default.
- W2741836698 hasConceptScore W2741836698C55493867 @default.
- W2741836698 hasConceptScore W2741836698C71924100 @default.
- W2741836698 hasConceptScore W2741836698C84699730 @default.
- W2741836698 hasConceptScore W2741836698C98274493 @default.
- W2741836698 hasLocation W27418366981 @default.
- W2741836698 hasOpenAccess W2741836698 @default.
- W2741836698 hasPrimaryLocation W27418366981 @default.
- W2741836698 hasRelatedWork W1910102050 @default.
- W2741836698 hasRelatedWork W1987797643 @default.
- W2741836698 hasRelatedWork W2098956886 @default.
- W2741836698 hasRelatedWork W2115592279 @default.
- W2741836698 hasRelatedWork W2125357027 @default.
- W2741836698 hasRelatedWork W2181669436 @default.
- W2741836698 hasRelatedWork W2274874094 @default.
- W2741836698 hasRelatedWork W2294658345 @default.
- W2741836698 hasRelatedWork W2347377711 @default.
- W2741836698 hasRelatedWork W2381432831 @default.
- W2741836698 hasRelatedWork W2389904373 @default.
- W2741836698 hasRelatedWork W2744749411 @default.
- W2741836698 hasRelatedWork W2883815525 @default.
- W2741836698 hasRelatedWork W2901199037 @default.
- W2741836698 hasRelatedWork W3000505109 @default.
- W2741836698 hasRelatedWork W3040490296 @default.
- W2741836698 hasRelatedWork W3094006962 @default.
- W2741836698 hasRelatedWork W3177794732 @default.
- W2741836698 hasRelatedWork W3197839958 @default.
- W2741836698 hasRelatedWork W2573124183 @default.
- W2741836698 isParatext "false" @default.
- W2741836698 isRetracted "false" @default.
- W2741836698 magId "2741836698" @default.
- W2741836698 workType "article" @default.