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- W2741891623 abstract "Spread of antimalarial drug resistance and superinfection poses a serious threat in the efficacy of most available antimalarial drugs. In this paper, a deterministic mathematical model for the spread of drug resistance malaria in human population is presented. A new way of modeling the superinfection is given by describing primary and secondary stages of malaria infection. The model also enables us to study the role of iron supplementation in superinfection. The effect of prolonging the primary infectious period and supplementation of iron in malaria superinfection and acquisition of temporal immunity are investigated. Numerical simulation results show that the duration of individuals in the primary infectious stage and iron supplements have no effect on the acquisition of immunity. Increasing the duration of primary infection period increases the risk of superinfection, and also effects the pattern of dominant parasite strains over different levels of transmission intensity. The model further shows that increasing the rate of iron supplementation increases superinfection with increase in transmission intensity. This finding has negative implications on the efficacy of antimalarial" @default.
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- W2741891623 date "2012-01-01" @default.
- W2741891623 modified "2023-10-07" @default.
- W2741891623 title "Spread of Antimalarial Drug Resistance in a Population with Superinfection" @default.
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