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- W2741936997 abstract "4 Abstract: Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphoge- nesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trig- ger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance. Keywords: Antifungal agents; Dermatomycoses; Drug resistance, fungal; Host-pathogen interactions Resumo: As micoses cutâneas estao entre as infeccoes mais comuns em humanos e se tornaram um importante problema de saude publica, principalmente por causarem infeccoes invasivas em pacientes imunodeprimidos. Durante a infeccao, a interacao dermatofito-hospedeiro desencadeia adaptacoes metabolicas especificas que permitem aos patogenos aderirem e penetrarem no tecido, remodelando seu metabolismo para captar nutrientes e superar os mecanismos de defesa do hospedeiro. Esse remo- delamento metabolico e a inter-relacao entre metabolismo, morfogenese e resposta ao estresse sao importantes fatores que estao sendo intensamente avaliados em diversos patogenos. As celulas do hos- pedeiro tambem respondem aos estimulos do patogeno, ativando vias de sinalizacao intracelular que culminam no desencadeamento de uma resposta imune contra o agente infeccioso. O entendimento molecular dessas respostas metabolicas pode ajudar no estabelecimento de novas estrategias terapeuti- cas. Nesta revisao, sao abordados diferentes aspectos da biologia dos dermatofitos, com enfase na inte- racao dermatofito-hospedeiro e nos mecanismos de resistencia a antifungicos. Palavras-chave: Antimicoticos; Dermatomicoses; Farmacorresistencia fungica; Interacoes hospedeiro-patogeno" @default.
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- W2741936997 date "2010-01-01" @default.
- W2741936997 modified "2023-09-24" @default.
- W2741936997 title "Dermatophytes: host-pathogen interaction and antifungal resistance * Dermatófitos: interação patógeno-hospedeiro e resistência a antifúngicos" @default.
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