Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741956075> ?p ?o ?g. }
- W2741956075 abstract "The myostatin (MSTN) gene is important because of its role in regulation of skeletal muscle growth in all vertebrates. In this study, CRISPR/Cas9 was utilized to successfully target the channel catfish, Ictalurus punctatus, muscle suppressor gene MSTN. CRISPR/Cas9 induced high rates (88-100%) of mutagenesis in the target protein-encoding sites of MSTN. MSTN-edited fry had more muscle cells (p < 0.001) than controls, and the mean body weight of gene-edited fry increased by 29.7%. The nucleic acid alignment of the mutated sequences against the wild-type sequence revealed multiple insertions and deletions. These results demonstrate that CRISPR/Cas9 is a highly efficient tool for editing the channel catfish genome, and opens ways for facilitating channel catfish genetic enhancement and functional genomics. This approach may produce growth-enhanced channel catfish and increase productivity." @default.
- W2741956075 created "2017-08-08" @default.
- W2741956075 creator A5001017638 @default.
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- W2741956075 date "2017-08-04" @default.
- W2741956075 modified "2023-10-11" @default.
- W2741956075 title "Generation of Myostatin Gene-Edited Channel Catfish (Ictalurus punctatus) via Zygote Injection of CRISPR/Cas9 System" @default.
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- W2741956075 doi "https://doi.org/10.1038/s41598-017-07223-7" @default.