Matches in SemOpenAlex for { <https://semopenalex.org/work/W2741999387> ?p ?o ?g. }
- W2741999387 abstract "The use of plant products as anti-microbial and immunostimulants has a traditional history and has contributed to the development of important therapeutic drugs used in modern medicine. The anti-cancer properties demonstrated so far by some plant-derived immunostimulants rely on the modulation of non-specific immune responses and do not directly affect immune memory cells. However, it should not be unexpected to find some plant-derived components being able to stimulate antigen-specific cell-mediated immunity in the context of vaccines. The identification of novel adjuvants would give further potential to the development of improved therapeutic anti-cancer vaccines, able to promote better presentation or immunogenicity of tumour antigens and to improve trafficking of effector T-cell populations to non-inflamed tumour sites. Among plant products with effects on microbes and immunity, beside many small secondary metabolites, there are also proteins and peptides and most of them are involved in the plant defence against pathogens and invading organisms. We will present data from our work on the use of plant compounds (as extracts, proteins or DNA sequences) as sources of innovative immunostimulants in the context of therapeutic vaccination of Human Papilloma Virus (HPV)-associated tumours. Further studies are required to determine the mechanism of action by which plant extracts and their active compounds (including secondary metabolites, proteins and peptides) exert their anti-cancer and adjuvant activity for their exploitation in therapeutic vaccines. Moreover, new in vivo and in vitro approaches to isolate novel adjuvant activities are needed." @default.
- W2741999387 created "2017-08-08" @default.
- W2741999387 creator A5085625578 @default.
- W2741999387 date "2012-01-01" @default.
- W2741999387 modified "2023-09-26" @default.
- W2741999387 title "Plant Genes and Plant Proteins as Adjuvants in Cancer Vaccination" @default.
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- W2741999387 hasPublicationYear "2012" @default.
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