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- W2742012247 abstract "Background: Clear definitions of normality are essential for correct interpretation of data, yet there is considerable variation in published normal ranges for cardiac output (CO)-derived haemodynamic variables. Methods: We analysed published data to obtain representative normal values (mean ± SD) for CO and six derived variables: CO (6.57 ± 1.19 L/min), stroke volume (SV, 86.2 ± 17.1 ml), cardiac index (CI, 3.49 ± 0.68 L/min/m2), systemic vascular resistance (SVR, 1060.5 ± 215.2 dynes.sec/cm5), pulmonary vascular resistance (PVR, 67.0 ± 23.0 dynes.sec/cm5), left ventricular stroke work (LVSW, 91.3 ± 21.8 gm-m/beat) and right ventricular stroke work (RVSW, 12.9 ± 4.1 gm-m/beat). Results: Reported normal ranges for SVR vary from either 800-1200 or 770-1500 or 1000-1500 dynes.sec/cm5 and normal ranges for PVR are either <250 or 20-120 dynes.sec/cm5, depending on the source There is no correlation between CI and body surface area (R2 = 0.1302). For PVR, it appears that reported values were originally calculated using the equation for total pulmonary resistance, since dropped from use, and were later indiscriminately applied to comparisons using the equation for PVR. Furthermore, it appears that all current references to mean values and normal ranges arise from a single seminal study by Barratt-Boyes and Wood in 1958, and form the basis for all commonly-used CO-derived haemodynamic variables without consideration of demographics such as age, sex, height, weight and race. Conclusion: Considering the diagnostic importance of PVR and other derived haemodynamic variables, a review of the validity and application of normal ranges that include patient demographics may be indicated." @default.
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- W2742012247 date "2017-01-01" @default.
- W2742012247 modified "2023-10-14" @default.
- W2742012247 title "Importance of Valid Reference Ranges for Cardiac Output-Derived Haemodynamic Variables" @default.
- W2742012247 doi "https://doi.org/10.1016/j.hlc.2017.06.214" @default.
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