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- W2742043232 abstract "andtwoclinical type bstrains, thecapsulation locus hadasingle copyofthis 17-kb segment, together with1.3kbofDNAidentified aslying between therepeats oftheduplicated locus. This1.3kbappears tobecrucial forcapsule production, since strains lacking it, although retaining a17-kb segment, werecapsule deficient. Oncomparing capsule polysaccharide production bythese three typebstrains withthatbya prototypic type bstrain withaduplicated locus, agenedosage effect wasdemonstrated, withahalving of detectable polysaccharide inthesingle-copy strains. Despite this reduction inpolysaccharide, these strains retained virulence potential asevidenced bybacteremia andmeningitis ininfant rats. Aswell assubserving augmented capsule polysaccharide production, aduplicated configuration ofthetype bcaplocus endows strains withgenetic instability notfoundincapsulate single-copy variants. We speculate thatasurvival advantage mightbeconferred onstrains carrying aduplication atthis locus asaresult ofgenedosage, the genetic instability ofthelocus, orboth." @default.
- W2742043232 created "2017-08-08" @default.
- W2742043232 creator A5022479870 @default.
- W2742043232 date "1988-01-01" @default.
- W2742043232 modified "2023-09-27" @default.
- W2742043232 title "Capsulation andGeneCopyNumberatthecapLocusof Haemophilus influenzae Typeb" @default.
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