Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742072716> ?p ?o ?g. }
- W2742072716 abstract "Proteinases and their inhibitors play impor- tant roles in neural development, homeostasis and dis- ease. Neuroserpin is a member of the serine proteinase inhibitor (serpin) superfamily that is secreted from the growth cones of neurons and inhibits the enzyme tissue- type plasminogen activator (tPA). The temporal and spa- tial pattern of neuroserpin expression suggests a role in synaptogenesis and is most prominent in areas of the brain that participate in learning, memory and behav- iour. Neuroserpin also provides neuronal protection in pathologies such as cerebral ischaemia and epilepsy by preventing excessive activity of tPA. Point mutations in neuroserpin cause aberrant conformational transi- tions and the formation of loop-sheet polymers that are retained within the endoplasmic reticulum of neurons, forming inclusion bodies that underlie an autosomal dominant dementia that we have called familial ence- phalopathy with neuroserpin inclusion bodies or FENIB. We review here the role of neuroserpin and other pro- teinase inhibitors in brain development, function and disease." @default.
- W2742072716 created "2017-08-08" @default.
- W2742072716 creator A5036734448 @default.
- W2742072716 creator A5082063678 @default.
- W2742072716 date "2006-01-01" @default.
- W2742072716 modified "2023-09-24" @default.
- W2742072716 title "Review Neuroserpin: a serpin to think about" @default.
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