Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742121982> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2742121982 endingPage "5739" @default.
- W2742121982 startingPage "5739" @default.
- W2742121982 abstract "Abstract Purpose: To determine the role of insulin-like growth factor (IGF)-I receptor (IGF-IR) in alpha 9 nicotinic acetylcholine receptor (α9-nAChR)-induced stemness-related properties and to assess the therapeutic potential for preventing early tumor relapse and metastasis of TNBCs. Experimental Design: Expression levels of stemness-related genes, α9-nAChR and IGF-IR in tissues (n = 67) were analyzed by real-time Q-PCR and the correlation of different gene levels were calculated by the Pearson correlation analysis. The effects of either α9-nAChR activation or IGF-1R transactivation on stemness expression in TNBC were examined using ALDEFLUOR assay with flow cytometry, RNA interference, wound closure/migration/invasion assay, and animal models. The α9-nAChR, OCT4 and IGF-1R protein, p-IGF-1R in tissues were detected by immunohistochemical staining. Results: A high positive correlation between the gene expression levels of OCT4/NANOG/CD24/CD44 and α9-nAChR/IGF-IR in human breast cancer tissues was observed. Nicotine induced α9-nAChR activation trans-activates an IGF-IR expression and a phosphorylation of STAT3, which stimulated stemness-related properties in both the cell lines and the xenografted mouse tumors. The inhibition of either α9-nAChR or IGF-IR activation by RNA interference significantly suppressed the nicotine-induced stemness-related properties and cell metastasis both in vitro and in vivo. Conclusions: IGF-1R signal regulates the nicotine/α9-nAChR-induced stemness properties and cell metastasis therefore convene poor prognosis in TNBCs. Citation Format: Yung-Che Kuo, Jan-Show Chu, Kha-Liang Lee, Victor James Drew, Wei-Zhan Zhuang, Chi-Long Chen, Yuan-Soon Ho, Yen-Hua Huang. Nicotine promotes stemness-related properties and cell migration/metastasis through IGF-1R regulation in triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5739. doi:10.1158/1538-7445.AM2017-5739" @default.
- W2742121982 created "2017-08-08" @default.
- W2742121982 creator A5021923650 @default.
- W2742121982 creator A5027192230 @default.
- W2742121982 creator A5034299172 @default.
- W2742121982 creator A5040212379 @default.
- W2742121982 creator A5045746901 @default.
- W2742121982 creator A5056774320 @default.
- W2742121982 creator A5076779528 @default.
- W2742121982 creator A5084321349 @default.
- W2742121982 date "2017-07-01" @default.
- W2742121982 modified "2023-10-18" @default.
- W2742121982 title "Abstract 5739: Nicotine promotes stemness-related properties and cell migration/metastasis through IGF-1R regulation in triple negative breast cancer" @default.
- W2742121982 doi "https://doi.org/10.1158/1538-7445.am2017-5739" @default.
- W2742121982 hasPublicationYear "2017" @default.
- W2742121982 type Work @default.
- W2742121982 sameAs 2742121982 @default.
- W2742121982 citedByCount "1" @default.
- W2742121982 countsByYear W27421219822021 @default.
- W2742121982 crossrefType "journal-article" @default.
- W2742121982 hasAuthorship W2742121982A5021923650 @default.
- W2742121982 hasAuthorship W2742121982A5027192230 @default.
- W2742121982 hasAuthorship W2742121982A5034299172 @default.
- W2742121982 hasAuthorship W2742121982A5040212379 @default.
- W2742121982 hasAuthorship W2742121982A5045746901 @default.
- W2742121982 hasAuthorship W2742121982A5056774320 @default.
- W2742121982 hasAuthorship W2742121982A5076779528 @default.
- W2742121982 hasAuthorship W2742121982A5084321349 @default.
- W2742121982 hasConcept C104317684 @default.
- W2742121982 hasConcept C107459253 @default.
- W2742121982 hasConcept C121608353 @default.
- W2742121982 hasConcept C126322002 @default.
- W2742121982 hasConcept C1292079 @default.
- W2742121982 hasConcept C145103041 @default.
- W2742121982 hasConcept C1491633281 @default.
- W2742121982 hasConcept C150194340 @default.
- W2742121982 hasConcept C170493617 @default.
- W2742121982 hasConcept C185592680 @default.
- W2742121982 hasConcept C188987157 @default.
- W2742121982 hasConcept C207701140 @default.
- W2742121982 hasConcept C2779013556 @default.
- W2742121982 hasConcept C2779492189 @default.
- W2742121982 hasConcept C2779547902 @default.
- W2742121982 hasConcept C2779570518 @default.
- W2742121982 hasConcept C2780110267 @default.
- W2742121982 hasConcept C2780932548 @default.
- W2742121982 hasConcept C502942594 @default.
- W2742121982 hasConcept C530470458 @default.
- W2742121982 hasConcept C54355233 @default.
- W2742121982 hasConcept C55493867 @default.
- W2742121982 hasConcept C71924100 @default.
- W2742121982 hasConcept C86803240 @default.
- W2742121982 hasConceptScore W2742121982C104317684 @default.
- W2742121982 hasConceptScore W2742121982C107459253 @default.
- W2742121982 hasConceptScore W2742121982C121608353 @default.
- W2742121982 hasConceptScore W2742121982C126322002 @default.
- W2742121982 hasConceptScore W2742121982C1292079 @default.
- W2742121982 hasConceptScore W2742121982C145103041 @default.
- W2742121982 hasConceptScore W2742121982C1491633281 @default.
- W2742121982 hasConceptScore W2742121982C150194340 @default.
- W2742121982 hasConceptScore W2742121982C170493617 @default.
- W2742121982 hasConceptScore W2742121982C185592680 @default.
- W2742121982 hasConceptScore W2742121982C188987157 @default.
- W2742121982 hasConceptScore W2742121982C207701140 @default.
- W2742121982 hasConceptScore W2742121982C2779013556 @default.
- W2742121982 hasConceptScore W2742121982C2779492189 @default.
- W2742121982 hasConceptScore W2742121982C2779547902 @default.
- W2742121982 hasConceptScore W2742121982C2779570518 @default.
- W2742121982 hasConceptScore W2742121982C2780110267 @default.
- W2742121982 hasConceptScore W2742121982C2780932548 @default.
- W2742121982 hasConceptScore W2742121982C502942594 @default.
- W2742121982 hasConceptScore W2742121982C530470458 @default.
- W2742121982 hasConceptScore W2742121982C54355233 @default.
- W2742121982 hasConceptScore W2742121982C55493867 @default.
- W2742121982 hasConceptScore W2742121982C71924100 @default.
- W2742121982 hasConceptScore W2742121982C86803240 @default.
- W2742121982 hasIssue "13_Supplement" @default.
- W2742121982 hasLocation W27421219821 @default.
- W2742121982 hasOpenAccess W2742121982 @default.
- W2742121982 hasPrimaryLocation W27421219821 @default.
- W2742121982 hasRelatedWork W1561288175 @default.
- W2742121982 hasRelatedWork W2000547292 @default.
- W2742121982 hasRelatedWork W2016293785 @default.
- W2742121982 hasRelatedWork W2067467096 @default.
- W2742121982 hasRelatedWork W2071015820 @default.
- W2742121982 hasRelatedWork W2604207380 @default.
- W2742121982 hasRelatedWork W2742121982 @default.
- W2742121982 hasRelatedWork W2886922911 @default.
- W2742121982 hasRelatedWork W3108889493 @default.
- W2742121982 hasRelatedWork W3158133282 @default.
- W2742121982 hasVolume "77" @default.
- W2742121982 isParatext "false" @default.
- W2742121982 isRetracted "false" @default.
- W2742121982 magId "2742121982" @default.
- W2742121982 workType "article" @default.