FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742123623> ?p ?o ?g. }

• W2742123623 endingPage "221" @default.
• W2742123623 startingPage "210" @default.
• W2742123623 abstract "Meniscal injury is one of the most common knee joint injuries, which remains an intractable challenge in clinical practice to date. Aberrant epidermal growth factor receptor (EGFR) activation levels in both human and mice menisci following injury, prompted us to investigate the functional role of EGFR by utilizing an inducible cartilage-specific EGFR-deficient mouse model. We demonstrated that conditional EGFR deletion in mice resulted in increased partial meniscectomy-induced ECM production within the meniscus, which is comparable to utilization of the small molecule EGFR inhibitor, gefitinib, to block EGFR activity. Here, we combined intra-articular delivery of gefitinib with an implanted customized collagen scaffold to substitute for lost meniscal tissue, as well as to promote meniscal regeneration and prevent osteoarthritis (OA) progression in a rabbit meniscectomy model. The main novelty of this study is the finding of a new application for small molecule EGFR inhibitor in meniscal injury therapy. This study also highlights the importance of using a customized collagen scaffold to provide robust mechanical strength and effectively promote meniscus regeneration. In summary, our study finds that intra-articular delivery of gefitinib together with implantation of a customized, multi-layer collagen scaffold not only enhanced meniscal regeneration, but also protected articular cartilage from degeneration in rabbit model. These results provide valuable insight for meniscal tissue engineering studies and clinical practice." @default.
• W2742123623 created "2017-08-08" @default.
• W2742123623 creator A5006772443 @default.
• W2742123623 creator A5008586677 @default.
• W2742123623 creator A5020330220 @default.
• W2742123623 creator A5027225242 @default.
• W2742123623 creator A5027835055 @default.
• W2742123623 creator A5042795296 @default.
• W2742123623 creator A5043414246 @default.
• W2742123623 creator A5049692788 @default.
• W2742123623 creator A5051584362 @default.
• W2742123623 creator A5058985073 @default.
• W2742123623 creator A5071867794 @default.
• W2742123623 creator A5078160004 @default.
• W2742123623 creator A5080191905 @default.
• W2742123623 creator A5082846858 @default.
• W2742123623 creator A5089714917 @default.
• W2742123623 date "2017-10-01" @default.
• W2742123623 modified "2023-10-15" @default.
• W2742123623 title "Delivery of epidermal growth factor receptor inhibitor via a customized collagen scaffold promotes meniscal defect regeneration in a rabbit model" @default.
• W2742123623 cites W1515929574 @default.
• W2742123623 cites W1547353239 @default.
• W2742123623 cites W1943111181 @default.
• W2742123623 cites W1970561503 @default.
• W2742123623 cites W1974756267 @default.
• W2742123623 cites W1976845881 @default.
• W2742123623 cites W1980397480 @default.
• W2742123623 cites W1988744840 @default.
• W2742123623 cites W1998866269 @default.
• W2742123623 cites W200402414 @default.
• W2742123623 cites W2005186825 @default.
• W2742123623 cites W2015354603 @default.
• W2742123623 cites W2019148337 @default.
• W2742123623 cites W2022097969 @default.
• W2742123623 cites W2023548097 @default.
• W2742123623 cites W2024894752 @default.
• W2742123623 cites W2029342200 @default.
• W2742123623 cites W2030036666 @default.
• W2742123623 cites W2032372303 @default.
• W2742123623 cites W2032955631 @default.
• W2742123623 cites W2037755817 @default.
• W2742123623 cites W2039799680 @default.
• W2742123623 cites W2044404885 @default.
• W2742123623 cites W2052606651 @default.
• W2742123623 cites W2057575379 @default.
• W2742123623 cites W2057741361 @default.
• W2742123623 cites W2063355095 @default.
• W2742123623 cites W2073195217 @default.
• W2742123623 cites W2075919717 @default.
• W2742123623 cites W2081755528 @default.
• W2742123623 cites W2082510662 @default.
• W2742123623 cites W2087183300 @default.
• W2742123623 cites W2096699701 @default.
• W2742123623 cites W2097010482 @default.
• W2742123623 cites W2098901994 @default.
• W2742123623 cites W2111301031 @default.
• W2742123623 cites W2112789125 @default.
• W2742123623 cites W2115473500 @default.
• W2742123623 cites W2118963985 @default.
• W2742123623 cites W2149766411 @default.
• W2742123623 cites W2151739612 @default.
• W2742123623 cites W2161887455 @default.
• W2742123623 cites W2165611865 @default.
• W2742123623 cites W2168702740 @default.
• W2742123623 cites W2188054376 @default.
• W2742123623 cites W335388451 @default.
• W2742123623 cites W4235484022 @default.
• W2742123623 cites W4292542165 @default.
• W2742123623 doi "https://doi.org/10.1016/j.actbio.2017.07.008" @default.
• W2742123623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28757192" @default.
• W2742123623 hasPublicationYear "2017" @default.
• W2742123623 type Work @default.
• W2742123623 sameAs 2742123623 @default.
• W2742123623 citedByCount "16" @default.
• W2742123623 countsByYear W27421236232018 @default.
• W2742123623 countsByYear W27421236232019 @default.
• W2742123623 countsByYear W27421236232020 @default.
• W2742123623 countsByYear W27421236232021 @default.
• W2742123623 countsByYear W27421236232022 @default.
• W2742123623 countsByYear W27421236232023 @default.
• W2742123623 crossrefType "journal-article" @default.
• W2742123623 hasAuthorship W2742123623A5006772443 @default.
• W2742123623 hasAuthorship W2742123623A5008586677 @default.
• W2742123623 hasAuthorship W2742123623A5020330220 @default.
• W2742123623 hasAuthorship W2742123623A5027225242 @default.
• W2742123623 hasAuthorship W2742123623A5027835055 @default.
• W2742123623 hasAuthorship W2742123623A5042795296 @default.
• W2742123623 hasAuthorship W2742123623A5043414246 @default.
• W2742123623 hasAuthorship W2742123623A5049692788 @default.
• W2742123623 hasAuthorship W2742123623A5051584362 @default.
• W2742123623 hasAuthorship W2742123623A5058985073 @default.
• W2742123623 hasAuthorship W2742123623A5071867794 @default.
• W2742123623 hasAuthorship W2742123623A5078160004 @default.
• W2742123623 hasAuthorship W2742123623A5080191905 @default.
• W2742123623 hasAuthorship W2742123623A5082846858 @default.
• W2742123623 hasAuthorship W2742123623A5089714917 @default.
• W2742123623 hasConcept C105702510 @default.
• W2742123623 hasConcept C120665830 @default.

• next