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- W2742147186 endingPage "817" @default.
- W2742147186 startingPage "817" @default.
- W2742147186 abstract "The provision of essential and non-essential amino acids for breast-fed infants is the major function of milk proteins. In addition, breast-fed infants might benefit from bioactivities of milk proteins, which are exhibited in the intestine during the digestive phase and by absorption of intact proteins or derived peptides. For lactoferrin, osteopontin and milk fat globule membrane proteins/lipids, which have not until recently been included in substantial amounts in infant formulas, in vitro experiments and animal models provide a convincing base of evidence for bioactivities, which contribute to the protection of the infant from pathogens, improve nutrient absorption, support the development of the immune system and provide components for optimal neurodevelopment. Technologies have become available to obtain these compounds from cow´s milk and the bovine compounds also exhibit bioactivities in humans. Randomized clinical trials with experimental infant formulas incorporating lactoferrin, osteopontin, or milk fat globule membranes have already provided some evidence for clinical benefits. This review aims to compare findings from laboratory and animal experiments with outcomes of clinical studies. There is good justification from basic science and there are promising results from clinical studies for beneficial effects of lactoferrin, osteopontin and the milk fat globule membrane complex of proteins and lipids. Further studies should ideally be adequately powered to investigate effects on clinically relevant endpoints in healthy term infants." @default.
- W2742147186 created "2017-08-08" @default.
- W2742147186 creator A5010181381 @default.
- W2742147186 creator A5019028903 @default.
- W2742147186 creator A5022733778 @default.
- W2742147186 creator A5071670795 @default.
- W2742147186 date "2017-07-28" @default.
- W2742147186 modified "2023-10-16" @default.
- W2742147186 title "Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants" @default.
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