FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742149025> ?p ?o ?g. }

• W2742149025 abstract "Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Adult male Sprague-Dawley rats were randomly divided into control and stressed groups, and were daily restrained in their motion (2.5 h/day) during 14 days. We found that chronic stress promotes an increase in c-Fos mRNA levels in both hippocampal areas, although it was observed a reduction in the immunoreactivity at pyramidal cell layer. Furthermore, Arc mRNAs levels were increased in both dorsal and VH, accompanied by an increase in Arc immunoreactivity in dendritic hippocampal layers. Furthermore, stress triggered a reduction in PSD-95 and NR1 protein levels in whole extract of dorsal and VH. Moreover, a reduction in NR2A/NR2B ratio was observed only in dorsal pole. In synaptosomal fractions, we detected a rise in NR1 in dorsal hippocampus (DH). By indirect immunofluorescence we found that NR1 subunits rise, especially in neuropil areas of dorsal, but not VH. In relation to AMPA receptor (AMPAR) subunits, chronic stress did not trigger any change, either in dorsal or ventral hippocampal areas. These data suggest that DH is more sensitive than VH to chronic stress exposure, mainly altering the expression of NMDA receptor (NMDAR) subunits, and probably favors changes in the configuration of this receptor that may influence the function of this area." @default.
• W2742149025 created "2017-08-08" @default.
• W2742149025 creator A5012957827 @default.
• W2742149025 creator A5015394053 @default.
• W2742149025 creator A5019980037 @default.
• W2742149025 creator A5026627205 @default.
• W2742149025 creator A5041001258 @default.
• W2742149025 creator A5054901336 @default.
• W2742149025 creator A5056654538 @default.
• W2742149025 creator A5060633304 @default.
• W2742149025 creator A5062925374 @default.
• W2742149025 creator A5070501593 @default.
• W2742149025 creator A5079139781 @default.
• W2742149025 creator A5084528618 @default.
• W2742149025 date "2017-08-10" @default.
• W2742149025 modified "2023-10-01" @default.
• W2742149025 title "Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats" @default.
• W2742149025 cites W1483876599 @default.
• W2742149025 cites W1495031753 @default.
• W2742149025 cites W1496673335 @default.
• W2742149025 cites W1535894955 @default.
• W2742149025 cites W1566828302 @default.
• W2742149025 cites W1572294349 @default.
• W2742149025 cites W1582811168 @default.
• W2742149025 cites W1598659526 @default.
• W2742149025 cites W1698044858 @default.
• W2742149025 cites W1814685953 @default.
• W2742149025 cites W1842151726 @default.
• W2742149025 cites W1883847229 @default.
• W2742149025 cites W1970851711 @default.
• W2742149025 cites W1977092358 @default.
• W2742149025 cites W1977550486 @default.
• W2742149025 cites W1978819318 @default.
• W2742149025 cites W1981864446 @default.
• W2742149025 cites W1982312356 @default.
• W2742149025 cites W1983011025 @default.
• W2742149025 cites W1985351207 @default.
• W2742149025 cites W1989003932 @default.
• W2742149025 cites W1991842868 @default.
• W2742149025 cites W1994362141 @default.
• W2742149025 cites W1998254077 @default.
• W2742149025 cites W1999236394 @default.
• W2742149025 cites W1999391547 @default.
• W2742149025 cites W2000547748 @default.
• W2742149025 cites W2002479123 @default.
• W2742149025 cites W2004305039 @default.
• W2742149025 cites W2005027803 @default.
• W2742149025 cites W2007506824 @default.
• W2742149025 cites W2010818798 @default.
• W2742149025 cites W2021199403 @default.
• W2742149025 cites W2031598294 @default.
• W2742149025 cites W2035310051 @default.
• W2742149025 cites W2041101385 @default.
• W2742149025 cites W2048560630 @default.
• W2742149025 cites W2051005796 @default.
• W2742149025 cites W2057374715 @default.
• W2742149025 cites W2060267954 @default.
• W2742149025 cites W2064790617 @default.
• W2742149025 cites W2064910482 @default.
• W2742149025 cites W2065169750 @default.
• W2742149025 cites W2069919701 @default.
• W2742149025 cites W2070501686 @default.
• W2742149025 cites W2071678249 @default.
• W2742149025 cites W2074385487 @default.
• W2742149025 cites W2074423856 @default.
• W2742149025 cites W2077785499 @default.
• W2742149025 cites W2084137319 @default.
• W2742149025 cites W2096472685 @default.
• W2742149025 cites W2098371930 @default.
• W2742149025 cites W2105006060 @default.
• W2742149025 cites W2106138734 @default.
• W2742149025 cites W2109105506 @default.
• W2742149025 cites W2110534885 @default.
• W2742149025 cites W2113944645 @default.
• W2742149025 cites W2116635659 @default.
• W2742149025 cites W2117439876 @default.
• W2742149025 cites W2121972943 @default.
• W2742149025 cites W2122384242 @default.
• W2742149025 cites W2123128644 @default.
• W2742149025 cites W2141391979 @default.
• W2742149025 cites W2142738469 @default.
• W2742149025 cites W2145735461 @default.
• W2742149025 cites W2148942933 @default.
• W2742149025 cites W2150525056 @default.
• W2742149025 cites W2153522818 @default.
• W2742149025 cites W2169578249 @default.
• W2742149025 cites W2171802424 @default.
• W2742149025 cites W2244087836 @default.
• W2742149025 cites W2335818909 @default.
• W2742149025 cites W2560155918 @default.
• W2742149025 cites W2569946795 @default.
• W2742149025 cites W2594030916 @default.
• W2742149025 cites W72199885 @default.
• W2742149025 doi "https://doi.org/10.3389/fnmol.2017.00244" @default.
• W2742149025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5554379" @default.
• W2742149025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28848384" @default.
• W2742149025 hasPublicationYear "2017" @default.
• W2742149025 type Work @default.
• W2742149025 sameAs 2742149025 @default.
• W2742149025 citedByCount "42" @default.

• next