FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742212198> ?p ?o ?g. }

• W2742212198 abstract "Given its prevalence and social impact, ASD (Autism Spectrum Disorder) is drawing much interest. Molecular basis of ASD is heterogeneous and only partially known. Many factors, including disorders comorbid with ASD, like TS (Tourette Syndrome), complicate ASD behavior-based diagnosis and make it vulnerable to bias. To further investigate ASD etiology and to identify potential biomarkers to support its precise diagnosis, we used TaqMan Low Density Array technology to profile serum miRNAs from ASD, TS, and TS+ASD patients, and unaffected controls (NCs). Through validation assays in 30 ASD, 24 TS, and 25 TS+ASD patients and 25 NCs, we demonstrated that miR-140-3p is upregulated in ASD vs: NC, TS, and TS+ASD (Tukey's test, p-values =0.03, =0.01, <0.0001, respectively). ΔCt values for miR-140-3p and YGTSS (Yale Global Tic Severity Scale) scores are positively correlated (Spearman r =0.33; Benjamini-Hochberg p-value =0.008) and show a linear relationship (p-value =0.002). Network functional analysis showed that nodes controlled by miR-140-3p, especially CD38 and NRIP1 which are its validated targets, are involved in processes convergingly dysregulated in ASD, such as synaptic plasticity, immune response, and chromatin binding. Biomarker analysis proved that serum miR-140-3p can discriminate among: (1) ASD and NC (Area under the ROC curve, AUC: 0.70; sensitivity: 63.33%; specificity: 68%); (2) ASD and TS (AUC: 0.72; sensitivity: 66.66%; specificity: 70.83%); (3) ASD and TS+ASD (AUC: 0.78; sensitivity: 73.33%; specificity: 76%). Characterization of miR-140-3p network would contribute to further clarify ASD etiology. Serum miR-140-3p could represent a potential non-invasive biomarker for ASD, easy to test through liquid biopsy." @default.
• W2742212198 created "2017-08-17" @default.
• W2742212198 creator A5003553304 @default.
• W2742212198 creator A5004414249 @default.
• W2742212198 creator A5017945502 @default.
• W2742212198 creator A5040548022 @default.
• W2742212198 creator A5042364234 @default.
• W2742212198 creator A5050770412 @default.
• W2742212198 creator A5053599983 @default.
• W2742212198 creator A5062306191 @default.
• W2742212198 creator A5063016748 @default.
• W2742212198 creator A5083795417 @default.
• W2742212198 date "2017-08-10" @default.
• W2742212198 modified "2023-09-27" @default.
• W2742212198 title "Expression and Regulatory Network Analysis of miR-140-3p, a New Potential Serum Biomarker for Autism Spectrum Disorder" @default.
• W2742212198 cites W1157930028 @default.
• W2742212198 cites W1484555099 @default.
• W2742212198 cites W1490898621 @default.
• W2742212198 cites W1497246181 @default.
• W2742212198 cites W1540070932 @default.
• W2742212198 cites W1559130469 @default.
• W2742212198 cites W1578173684 @default.
• W2742212198 cites W1731958606 @default.
• W2742212198 cites W1744273349 @default.
• W2742212198 cites W1809124392 @default.
• W2742212198 cites W1883315382 @default.
• W2742212198 cites W1912680100 @default.
• W2742212198 cites W1920972969 @default.
• W2742212198 cites W1928264125 @default.
• W2742212198 cites W1940044521 @default.
• W2742212198 cites W1950907231 @default.
• W2742212198 cites W1951304988 @default.
• W2742212198 cites W1964904043 @default.
• W2742212198 cites W1968300632 @default.
• W2742212198 cites W1973137505 @default.
• W2742212198 cites W1974469992 @default.
• W2742212198 cites W1975867021 @default.
• W2742212198 cites W1984130633 @default.
• W2742212198 cites W1985187126 @default.
• W2742212198 cites W1987131356 @default.
• W2742212198 cites W1987617697 @default.
• W2742212198 cites W1995378874 @default.
• W2742212198 cites W1995647101 @default.
• W2742212198 cites W2004694780 @default.
• W2742212198 cites W2010345670 @default.
• W2742212198 cites W2013868665 @default.
• W2742212198 cites W2014427218 @default.
• W2742212198 cites W2015320368 @default.
• W2742212198 cites W2015806758 @default.
• W2742212198 cites W2018736722 @default.
• W2742212198 cites W2020541351 @default.
• W2742212198 cites W2021010268 @default.
• W2742212198 cites W2023044037 @default.
• W2742212198 cites W2024511327 @default.
• W2742212198 cites W2028897231 @default.
• W2742212198 cites W2029232508 @default.
• W2742212198 cites W2033671805 @default.
• W2742212198 cites W2035618305 @default.
• W2742212198 cites W2045050188 @default.
• W2742212198 cites W2045638840 @default.
• W2742212198 cites W2048596172 @default.
• W2742212198 cites W2051740071 @default.
• W2742212198 cites W2053161513 @default.
• W2742212198 cites W2054767601 @default.
• W2742212198 cites W2056508664 @default.
• W2742212198 cites W2062744218 @default.
• W2742212198 cites W2064698468 @default.
• W2742212198 cites W2069696742 @default.
• W2742212198 cites W2071516720 @default.
• W2742212198 cites W2075765362 @default.
• W2742212198 cites W2077232248 @default.
• W2742212198 cites W2077251459 @default.
• W2742212198 cites W2078812502 @default.
• W2742212198 cites W2079529928 @default.
• W2742212198 cites W2088875650 @default.
• W2742212198 cites W2092284159 @default.
• W2742212198 cites W2094636384 @default.
• W2742212198 cites W2097233439 @default.
• W2742212198 cites W2097872763 @default.
• W2742212198 cites W2100809769 @default.
• W2742212198 cites W2101179009 @default.
• W2742212198 cites W2102844520 @default.
• W2742212198 cites W2103112346 @default.
• W2742212198 cites W2111514154 @default.
• W2742212198 cites W2114570899 @default.
• W2742212198 cites W2115277036 @default.
• W2742212198 cites W2115655974 @default.
• W2742212198 cites W2118258530 @default.
• W2742212198 cites W2118368353 @default.
• W2742212198 cites W2118816476 @default.
• W2742212198 cites W2119321292 @default.
• W2742212198 cites W2121367992 @default.
• W2742212198 cites W2121580962 @default.
• W2742212198 cites W2125972315 @default.
• W2742212198 cites W2126576871 @default.
• W2742212198 cites W2129034977 @default.
• W2742212198 cites W2133365560 @default.
• W2742212198 cites W2133658633 @default.
• W2742212198 cites W2135059214 @default.
• W2742212198 cites W2138125988 @default.

• next