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- W2742221608 abstract "During the development of the olfactory bulb shows great cytological plasticity, being a widely used model to try to understand the mechanisms involved in neuronal growth and their functionalism, having consideration that it is a system establishing diversity of synaptic interactions. The purpose of this study was to know the process of formation of axodendritic and dendrodendritic synaptic contacts during the development of the olfactory bulb. Were used NMRI mice from NMRI mice were used from 17 days embryonic (E) until to 9 days postnatal (P). The tissue was processed for ultrastructural study, and variance analysis (ANOVA) was performed using the statistical program SPSS version 15. At E17 internal thickening were observed in axonal and dendritic membranes, and synaptic vesicles attached in proximity to the membrane thickenings, which increased in number and thickness older ages. Axodendritic synapses immature increase in size, thickness and number from E17 until P7, and the following quantitative differences are identified: between E17 and E19 there was an increase of 39.8%, from E19 to E21 of 4.95%, between E21 and P0 there was of 5.84%, P1 day there was a difference of 16.58% over the previous day, and from this day until P7 there was a continuous increase in the number of synapses. Moreover, the formation of dendrodendritic synapses is an exclusively postnatal phenomenon that starts the day P3, increasing their number up to P7, as evidenced by the following data found: between P3 and P5 there was a difference of 41.03% between P5 and P7 of 54.02%, and between P7 and P9 the difference there was 61.5%. In conclusion, the amount of axodendritic and dendrodendritic synapses increased until P7 day; and was at P9 when both synapses reached morphological maturity." @default.
- W2742221608 created "2017-08-17" @default.
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- W2742221608 date "2015-01-06" @default.
- W2742221608 modified "2023-09-24" @default.
- W2742221608 title "Ultrastructural Study of Synaptogenesis in the Olfactory Bulb NMRI Mice" @default.
- W2742221608 hasPublicationYear "2015" @default.
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