FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742222732> ?p ?o ?g. }

• W2742222732 abstract "ABSTRACT In 2014 and 2015, the United States experienced an unprecedented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus. Initial cases affected mainly wild birds and mixed backyard poultry species, while later outbreaks affected mostly commercial chickens and turkeys. The pathogenesis, transmission, and intrahost evolutionary dynamics of initial Eurasian H5N8 and reassortant H5N2 clade 2.3.4.4 HPAI viruses in the United States were investigated in minor gallinaceous poultry species (i.e., species for which the U.S. commercial industries are small), namely, Japanese quail, bobwhite quail, pearl guinea fowl, chukar partridges, and ring-necked pheasants. Low mean bird infectious doses (<2 to 3.7 log 10 ) support direct introduction and infection of these species as observed in mixed backyard poultry during the early outbreaks. Pathobiological features and systemic virus replication in all species tested were consistent with HPAI virus infection. Sustained virus shedding with transmission to contact-exposed birds, alongside long incubation periods, may enable unrecognized dissemination and adaptation to other gallinaceous species, such as chickens and turkeys. Genome sequencing of excreted viruses revealed numerous low-frequency polymorphisms and 20 consensus-level substitutions in all genes and species, but especially in Japanese quail and pearl guinea fowl and in internal proteins PB1 and PB2. This genomic flexibility after only one passage indicates that influenza viruses can continue to evolve in galliform species, increasing their opportunity to adapt to other species. Our findings suggest that these gallinaceous poultry are permissive for infection and sustainable transmissibility with the 2014 initial wild bird-adapted clade 2.3.4.4 virus, with potential acquisition of mutations leading to host range adaptation. IMPORTANCE The outbreak of clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus that occurred in the United States in 2014 and 2015 represents the worst livestock disease event in the country, with unprecedented socioeconomic and commercial consequences. Epidemiological and molecular investigations can identify transmission pathways of the HPAI virus. However, understanding the pathogenesis, transmission, and intrahost evolutionary dynamics of new HPAI viruses in different avian species is paramount. The significance of our research is in examining the susceptibility of minor gallinaceous species to HPAI virus, as this poultry sector also suffers from HPAI epizootics, and identifying the biological potential of these species as an epidemiological link between the waterfowl reservoir and the commercial chicken and turkey populations, with the ultimate goal of refining surveillance in these populations to enhance early detection, management, and control in future HPAI virus outbreaks." @default.
• W2742222732 created "2017-08-17" @default.
• W2742222732 creator A5019669992 @default.
• W2742222732 creator A5050674173 @default.
• W2742222732 creator A5067875564 @default.
• W2742222732 creator A5069055367 @default.
• W2742222732 creator A5083854191 @default.
• W2742222732 creator A5084458656 @default.
• W2742222732 creator A5090505661 @default.
• W2742222732 date "2017-11-01" @default.
• W2742222732 modified "2023-10-16" @default.
• W2742222732 title "Pathobiology of Clade 2.3.4.4 H5Nx High-Pathogenicity Avian Influenza Virus Infections in Minor Gallinaceous Poultry Supports Early Backyard Flock Introductions in the Western United States in 2014-2015" @default.
• W2742222732 cites W113531246 @default.
• W2742222732 cites W1511685887 @default.
• W2742222732 cites W1566744867 @default.
• W2742222732 cites W1603867145 @default.
• W2742222732 cites W1686286415 @default.
• W2742222732 cites W1963673465 @default.
• W2742222732 cites W1963675143 @default.
• W2742222732 cites W1967419402 @default.
• W2742222732 cites W1971405199 @default.
• W2742222732 cites W1986729212 @default.
• W2742222732 cites W1987052745 @default.
• W2742222732 cites W1989481626 @default.
• W2742222732 cites W1992510841 @default.
• W2742222732 cites W1993296569 @default.
• W2742222732 cites W1995994338 @default.
• W2742222732 cites W2000811678 @default.
• W2742222732 cites W2004036876 @default.
• W2742222732 cites W2021388889 @default.
• W2742222732 cites W2023892549 @default.
• W2742222732 cites W2029890121 @default.
• W2742222732 cites W2032967479 @default.
• W2742222732 cites W2034970371 @default.
• W2742222732 cites W2037217798 @default.
• W2742222732 cites W2052111111 @default.
• W2742222732 cites W2053603272 @default.
• W2742222732 cites W2058937798 @default.
• W2742222732 cites W2059334667 @default.
• W2742222732 cites W2060377782 @default.
• W2742222732 cites W2065893540 @default.
• W2742222732 cites W2066239994 @default.
• W2742222732 cites W2068880378 @default.
• W2742222732 cites W2075469536 @default.
• W2742222732 cites W2077819494 @default.
• W2742222732 cites W2084527283 @default.
• W2742222732 cites W2085066737 @default.
• W2742222732 cites W2091473676 @default.
• W2742222732 cites W2092097938 @default.
• W2742222732 cites W2094610316 @default.
• W2742222732 cites W2099235928 @default.
• W2742222732 cites W2099595459 @default.
• W2742222732 cites W2102600150 @default.
• W2742222732 cites W2111133933 @default.
• W2742222732 cites W2113884542 @default.
• W2742222732 cites W2117690097 @default.
• W2742222732 cites W2123679254 @default.
• W2742222732 cites W2130854633 @default.
• W2742222732 cites W2136570341 @default.
• W2742222732 cites W2146335827 @default.
• W2742222732 cites W2148734478 @default.
• W2742222732 cites W2154111571 @default.
• W2742222732 cites W2154234108 @default.
• W2742222732 cites W2155212156 @default.
• W2742222732 cites W2157049563 @default.
• W2742222732 cites W2162791376 @default.
• W2742222732 cites W2169318727 @default.
• W2742222732 cites W2176066519 @default.
• W2742222732 cites W2212888210 @default.
• W2742222732 cites W2264339593 @default.
• W2742222732 cites W2266876246 @default.
• W2742222732 cites W2286371111 @default.
• W2742222732 cites W2291738852 @default.
• W2742222732 cites W2343514312 @default.
• W2742222732 cites W2396488765 @default.
• W2742222732 cites W2406460005 @default.
• W2742222732 cites W2406624329 @default.
• W2742222732 cites W2410276431 @default.
• W2742222732 cites W2464779428 @default.
• W2742222732 cites W2508008679 @default.
• W2742222732 cites W2549979091 @default.
• W2742222732 cites W2550594255 @default.
• W2742222732 cites W2564795022 @default.
• W2742222732 cites W2591977055 @default.
• W2742222732 cites W2624476933 @default.
• W2742222732 cites W4210950604 @default.
• W2742222732 cites W2064621693 @default.
• W2742222732 doi "https://doi.org/10.1128/jvi.00960-17" @default.
• W2742222732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5640860" @default.
• W2742222732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28794040" @default.
• W2742222732 hasPublicationYear "2017" @default.
• W2742222732 type Work @default.
• W2742222732 sameAs 2742222732 @default.
• W2742222732 citedByCount "25" @default.
• W2742222732 countsByYear W27422227322017 @default.
• W2742222732 countsByYear W27422227322018 @default.
• W2742222732 countsByYear W27422227322019 @default.
• W2742222732 countsByYear W27422227322020 @default.
• W2742222732 countsByYear W27422227322021 @default.
• W2742222732 countsByYear W27422227322022 @default.

• next