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- W2742240523 abstract "Chronic low-grade systemic inflammation represents a mechanism common to many diseases linked to atherosclerosis-related pathways. There is a growing body of evidence indicating that the combination of food quantity and quality along with genetic susceptibility are able to induce the aberrant activation of innate immune signalling, which initially contributes to chronic low-grade inflammation. Liver represents the central player to inflammatory response. Dietary/metabolic factors contribute to the pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD), the main causes of liver disease in the Western world. Enlargement of the spleen, central organ in regulating the inflammation-related immune response, is commonly seen in patients with of NAFLD, depicting the so called liver-spleen axis. The aim of this review was to provide an at-a-glance overview of the possible bi-directional mechanisms linking nutrition and inflammation, particularly pinpointing the inflammatory effects stemmed by nutrition on liver-spleen axis. In particular, the role of unhealthy diet, healthy dietary patterns, such as the Mediterranean diet style, dietary vitamins and micronutrients, such as vitamin D or Magnesium, and Glucagon-Like Peptide-1, a well-known incretin released in response to meal intake, will be discussed. The highly variability of the inflammatory response highlights the role of expert nutritionists in refining methodologies apt to assess nutritional epidemiology and to apply appropriate dietary intervention to counteract diet-induced inflammation mechanisms." @default.
- W2742240523 created "2017-08-17" @default.
- W2742240523 creator A5003201082 @default.
- W2742240523 creator A5015141404 @default.
- W2742240523 creator A5045618604 @default.
- W2742240523 creator A5058627211 @default.
- W2742240523 creator A5066892710 @default.
- W2742240523 creator A5070034601 @default.
- W2742240523 creator A5079494293 @default.
- W2742240523 creator A5087293057 @default.
- W2742240523 date "2017-11-30" @default.
- W2742240523 modified "2023-10-06" @default.
- W2742240523 title "Nutrition, inflammation and liver-spleen axis" @default.
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