Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742252362> ?p ?o ?g. }
- W2742252362 abstract "Cell migration is one of the many processes orchestrated by calcium (Ca2+) signaling, and its dysregulation drives the increased invasive and metastatic potential of cancer cells. The ability of Ca2+ to function effectively as a regulator of migration requires the generation of temporally complex signals within spatially restricted microdomains. The generation and maintenance of these Ca2+ signals require a specific structural architecture and tightly regulated communication between the extracellular space, intracellular organelles and cytoplasmic compartments. New insights into how Ca2+ microdomains are shaped by inter-organellar Ca2+ communication have shed light on how Ca2+ coordinates cell migration by directing cellular polarization and the rearrangement of structural proteins. Importantly, we are beginning to understand how cancer subverts normal migration through the activity of oncogenes and tumor suppressors that impinge directly on the physiological function or expression levels of Ca2+ signaling proteins. In this review, we present and discuss research at the forefront of inter-organellar Ca2+ signaling as it relates to cell migration, metastasis and cancer progression, with special focus on ER-to-mitochondrial Ca2+ transfer." @default.
- W2742252362 created "2017-08-17" @default.
- W2742252362 creator A5034958079 @default.
- W2742252362 date "2017-08-10" @default.
- W2742252362 modified "2023-10-18" @default.
- W2742252362 title "The Regulation of Tumor Cell Invasion and Metastasis by Endoplasmic Reticulum-to-Mitochondrial Ca2+ Transfer" @default.
- W2742252362 cites W1516531545 @default.
- W2742252362 cites W1550719001 @default.
- W2742252362 cites W1867774516 @default.
- W2742252362 cites W1934528477 @default.
- W2742252362 cites W1964081206 @default.
- W2742252362 cites W1967184808 @default.
- W2742252362 cites W1969709153 @default.
- W2742252362 cites W1973523055 @default.
- W2742252362 cites W1974114145 @default.
- W2742252362 cites W1979018398 @default.
- W2742252362 cites W1980804643 @default.
- W2742252362 cites W1983512359 @default.
- W2742252362 cites W1985924867 @default.
- W2742252362 cites W1986213783 @default.
- W2742252362 cites W1986440776 @default.
- W2742252362 cites W1986531910 @default.
- W2742252362 cites W1987088763 @default.
- W2742252362 cites W1990408088 @default.
- W2742252362 cites W1991055482 @default.
- W2742252362 cites W1991820222 @default.
- W2742252362 cites W1997187136 @default.
- W2742252362 cites W1998447416 @default.
- W2742252362 cites W1998654006 @default.
- W2742252362 cites W1999030622 @default.
- W2742252362 cites W2000115025 @default.
- W2742252362 cites W2002233209 @default.
- W2742252362 cites W2002439304 @default.
- W2742252362 cites W2002475003 @default.
- W2742252362 cites W2004580960 @default.
- W2742252362 cites W2005216847 @default.
- W2742252362 cites W2005334224 @default.
- W2742252362 cites W2007491346 @default.
- W2742252362 cites W2007508922 @default.
- W2742252362 cites W2009657046 @default.
- W2742252362 cites W2011848873 @default.
- W2742252362 cites W2012598982 @default.
- W2742252362 cites W2015679500 @default.
- W2742252362 cites W2015946977 @default.
- W2742252362 cites W2016369260 @default.
- W2742252362 cites W2019079031 @default.
- W2742252362 cites W2019961716 @default.
- W2742252362 cites W2020379023 @default.
- W2742252362 cites W2022495797 @default.
- W2742252362 cites W2023234570 @default.
- W2742252362 cites W2023283007 @default.
- W2742252362 cites W2030637794 @default.
- W2742252362 cites W2033559853 @default.
- W2742252362 cites W2036145275 @default.
- W2742252362 cites W2036757369 @default.
- W2742252362 cites W2038468721 @default.
- W2742252362 cites W2040155866 @default.
- W2742252362 cites W2046178144 @default.
- W2742252362 cites W2046353863 @default.
- W2742252362 cites W2049193842 @default.
- W2742252362 cites W2054645758 @default.
- W2742252362 cites W2056351479 @default.
- W2742252362 cites W2059610488 @default.
- W2742252362 cites W2061613974 @default.
- W2742252362 cites W2063220206 @default.
- W2742252362 cites W2064638211 @default.
- W2742252362 cites W2065018825 @default.
- W2742252362 cites W2065915608 @default.
- W2742252362 cites W2067841051 @default.
- W2742252362 cites W2068048197 @default.
- W2742252362 cites W2070143299 @default.
- W2742252362 cites W2072752280 @default.
- W2742252362 cites W2075569239 @default.
- W2742252362 cites W2076598575 @default.
- W2742252362 cites W2077807460 @default.
- W2742252362 cites W2078179312 @default.
- W2742252362 cites W2080232352 @default.
- W2742252362 cites W2081848364 @default.
- W2742252362 cites W2083502135 @default.
- W2742252362 cites W2084281549 @default.
- W2742252362 cites W2085719701 @default.
- W2742252362 cites W2090240729 @default.
- W2742252362 cites W2093672972 @default.
- W2742252362 cites W2096007038 @default.
- W2742252362 cites W2096331437 @default.
- W2742252362 cites W2096460732 @default.
- W2742252362 cites W2096579721 @default.
- W2742252362 cites W2100173413 @default.
- W2742252362 cites W2102525336 @default.
- W2742252362 cites W2110375403 @default.
- W2742252362 cites W2115021528 @default.
- W2742252362 cites W2115470184 @default.
- W2742252362 cites W2117403796 @default.
- W2742252362 cites W2117554463 @default.
- W2742252362 cites W2117692326 @default.
- W2742252362 cites W2121330845 @default.
- W2742252362 cites W2121952176 @default.
- W2742252362 cites W2129527640 @default.
- W2742252362 cites W2130434635 @default.
- W2742252362 cites W2130881126 @default.